Home Metabolism PDE inhibitor Vardenafil hydrochloride For research use only.

Vardenafil hydrochloride

Synonyms: BAY38-9456, Levitra, Staxyn

Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.

Vardenafil hydrochloride Chemical Structure

Vardenafil hydrochloride Chemical Structure

CAS: 224785-91-5

Selleck's Vardenafil hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S595701 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 20 mg/mL] false Purity: 99.53%
99.53

Vardenafil hydrochloride Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Choose Selective PDE Inhibitors

Biological Activity

Description Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.
Targets
PDE5 [1]
(Cell-free assay)		 PDE6 [1]
(Cell-free assay)		 PDE1 [1]
(Cell-free assay)
0.7 nM 11 nM 180 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01207947 Completed
Erectile Dysfunction
Bayer
 October 2007 --
NCT00909233 Completed
Erectile Dysfunction
Bayer
 August 2007 --

Chemical Information & Solubility

Molecular Weight 525.06 Formula

C23H33ClN6O4S
CAS No. 224785-91-5 SDF --
Smiles Cl.CCCC1=NC(=C2[N]1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S](=O)(=O)N4CCN(CC)CC4)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (190.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 20 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Vardenafil hydrochloride | Vardenafil hydrochloride supplier | purchase Vardenafil hydrochloride | Vardenafil hydrochloride cost | Vardenafil hydrochloride manufacturer | order Vardenafil hydrochloride | Vardenafil hydrochloride distributor