CAS No. 90-50-6
Batch:
Purity:99.69
Chemical Structure
Check the
3,4,5-Trimethoxycinnamic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 90-50-6 | |
|---|---|---|
| Molecular Formula |
C12H14O5 |
|
| Molecular Weight (MW) | 238.24 | |
| SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)O |
3,4,5-Trimethoxycinnamic acid is a natural constituent of Polygalae Radix that acts as a central nervous system modulator targeting the GABAA/benzodiazepine receptor complex. By interacting with GABAA receptors, this compound enhances GABAergic neurotransmission to attenuate neuronal hyperexcitability. This signaling pathway modulation contributes to downstream neuroprotective, anti-seizure, and sedative phenotypes, highlighting its role as an active neuropharmacological agent. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(197.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 3,4,5-Trimethoxycinnamic acid Solubility in DMSO
- 3,4,5-Trimethoxycinnamic acid Stock Solution
- 3,4,5-Trimethoxycinnamic acid Storage
- 3,4,5-Trimethoxycinnamic acid Stability
- 3,4,5-Trimethoxycinnamic acid Molecular Weight
- 3,4,5-Trimethoxycinnamic acid SMILES
- 3,4,5-Trimethoxycinnamic acid Chemical Structure (2D and 3D)
- 3,4,5-Trimethoxycinnamic acid SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.