Tiratricol

Catalog No.S4185

For research use only.

Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.

Tiratricol Chemical Structure

CAS No. 51-24-1

Purity & Quality Control

Choose Selective THR Inhibitors

Biological Activity

Description Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.
In vitro

Tiratricol is indicated in the management of thyroid hormone resistance syndrome and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer. [1] It has been investigated for use in reducing goiter.[2] It has also shown some effectiveness in reducing the atrophy caused when using corticosteroids.[3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(160.78 mM)
Ethanol 100 mg/mL
(160.78 mM)
Water Insoluble

Chemical Information

Molecular Weight 621.93
Formula

C14H9I3O4

CAS No. 51-24-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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