Eprotirome (KB2115)

Catalog No.S0343

For research use only.

Eprotirome (KB2115) is a liver-selective agonist of thyroid hormone receptor (TR). Eprotirome is investigated for the potential treatment of dyslipidemias and obesity.

Eprotirome (KB2115) Chemical Structure

CAS No. 355129-15-6

Purity & Quality Control

Choose Selective THR Inhibitors

Biological Activity

Description Eprotirome (KB2115) is a liver-selective agonist of thyroid hormone receptor (TR). Eprotirome is investigated for the potential treatment of dyslipidemias and obesity.
Targets
THR [1]
In vivo

Eprotirome (KB2115) reduces hepatic steatosis substantially, selectively activates TRβ target genes in the liver.[3]

Protocol (from reference)

Animal Research:

[3]

  • Animal Models: ob/ob mice
  • Dosages: 3 mg/kg/diet
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 487.14
Formula
C18H17Br2NO5
CAS No. 355129-15-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C1=C(C=CC(=C1)OC2=C(C=C(C=C2Br)NC(=O)CC(=O)O)Br)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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