Numerous clinical trials evaluate topotecan across Early Phase 1 through Phase 4 for oncologic and non-oncologic indications, primarily targeting epithelial ovarian cancer, small cell lung cancer, retinoblastoma, solid tumors, acute myeloid leukemia, and exploratory COVID-19 respiratory infections. Encompassing completed, active, recruiting, and terminated statuses, these studies evaluate protocols such as Phase 2 combination regimens for myeloproliferative disorders and Phase 3 comparative trials in platinum-resistant ovarian cancer. Clinical research is supported by diverse sponsors, including academic institutions, medical centers, government bodies like the National Cancer Institute, and pharmaceutical entities.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05535166 | RECRUITING | Medulloblastoma |
St. Jude Children's Research Hospital |
2022-12-20 | PHASE2 |
| NCT04681417 | RECRUITING | Retinoblastoma |
Institut Curie |
2021-03-25 | PHASE2; PHASE3 |
| NCT07321912 | RECRUITING | Osteosarcoma; Ewing Sarcoma |
Milton S. Hershey Medical Center |
2026-06-05 | PHASE2 |
| NCT05521984 | RECRUITING | Pediatric Brain Tumor; Pediatric Solid Tumor |
Washington University School of Medicine |
2023-04-03 | PHASE1 |
| NCT02813135 | RECRUITING | Pediatric Cancer |
Gustave Roussy, Cancer Campus, Grand Paris |
2016-08-03 | PHASE1; PHASE2 |
| NCT07334301 | RECRUITING | Relapsed Neuroblastoma |
University of Birmingham |
2024-11-11 | PHASE1; PHASE2 |
| NCT06942039 | RECRUITING | CNS Embryonal Tumor; CNS, Medulloblastoma; Atypical Teratoid Rhabdoid Tumor; Medulloblastoma, Childhood; Medulloblastoma, Group 3; Medulloblastoma, Group 4; Pineoblastoma; Neuroblastoma; Embryonal Tumor With Multilayered Rosettes; Embryonal Tumor With Abundant Neuropil and True Rosettes; Ependymoblastoma; Medulloepithelioma; CNS Embryonal Tumor With Rhabdoid Features; CNS Embryonal Tumor, Nos |
C17 Council |
2025-09-23 | EARLY_PHASE1 |
| NCT07194044 | RECRUITING | Metastatic Ewing Sarcoma |
H. Lee Moffitt Cancer Center and Research Institute |
2026-02-05 | PHASE1 |
| NCT03126916 | RECRUITING | Ganglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma |
Children's Oncology Group |
2018-05-14 | PHASE3 |
| NCT07365241 | RECRUITING | Small Cell Lung Cancer |
AbbVie |
2026-07-02 | PHASE3 |
| NCT07141771 | NOT_YET_RECRUITING | SCLC, Extensive Stage |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2025-12-31 | PHASE1; PHASE2 |
| NCT06172296 | RECRUITING | Ganglioneuroblastoma, Nodular; Neuroblastoma |
National Cancer Institute (NCI) |
2024-04-19 | PHASE3 |
| NCT07286266 | RECRUITING | Ovarian Neoplasms |
GlaxoSmithKline |
2026-06-18 | PHASE3 |
| NCT06679634 | RECRUITING | Retinoblastoma |
Targeted Therapy Technologies, LLC |
2025-02-21 | PHASE2 |
| NCT07708753 | NOT_YET_RECRUITING | Platinum-resistant Ovarian Cancer; Platinum-resistant Primary Peritoneal Cancer; Platinum-resistant Fallopian Tube Cancer |
CSPC Megalith Biopharmaceutical Co.,Ltd. |
2026-07-01 | PHASE3 |
| NCT06801834 | RECRUITING | Extensive Stage Small Cell Lung Cancer (ES-SCLC) |
Gilead Sciences |
2025-04-04 | PHASE3 |
| NCT07437963 | NOT_YET_RECRUITING | Recurrent Ganglioneuroblastoma; Recurrent Neuroblastoma; Refractory Ganglioneuroblastoma; Refractory Neuroblastoma |
National Cancer Institute (NCI) |
2026-10-28 | PHASE1; PHASE2 |
| NCT06528496 | RECRUITING | High-risk Neuroblastoma; Neuroblastoma; Childhood Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2024-07-22 | PHASE2 |
| NCT06647953 | RECRUITING | Pleuropulmonary Blastoma |
Children's Oncology Group |
2025-03-21 | PHASE3 |
| NCT07797153 | NOT_YET_RECRUITING | Recurrent or Metastatic Cervical Cancer |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
2026-09 | PHASE3 |
| NCT07545460 | NOT_YET_RECRUITING | Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2026-07 | PHASE3 |
| NCT07218809 | RECRUITING | Epithelial Ovarian Cancer |
AstraZeneca |
2025-12-29 | PHASE3 |
| NCT07213804 | RECRUITING | Ovarian Neoplasms; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Neoplasm Metastasis |
Eli Lilly and Company |
2025-10-22 | PHASE3 |
| NCT07189455 | RECRUITING | Small-cell Lung Cancer |
Suzhou Zelgen Biopharmaceuticals Co.,Ltd |
2025-12-12 | PHASE3 |
| NCT07371663 | RECRUITING | Solid Cancers; NSCLC (Advanced Non-small Cell Lung Cancer); Gastric (Stomach) Cancer; Endometrial Cancer; Malignant Melanoma |
Beijing Tide Pharmaceutical Co., Ltd |
2025-12-03 | PHASE1; PHASE2 |
| NCT07076095 | NOT_YET_RECRUITING | Small Cell Lung Cancer |
SUNHO（China）BioPharmaceutical CO., Ltd. |
2025-08-01 | PHASE2 |
| NCT05800587 | RECRUITING | Lung Cancer; Small-cell Lung Cancer; Non Small Cell Lung Cancer |
Fox Chase Cancer Center |
2023-02-22 | PHASE2 |
| NCT06459180 | ACTIVE_NOT_RECRUITING | Cervical Cancer |
Merck Sharp & Dohme LLC |
2024-07-24 | PHASE3 |
| NCT06128837 | RECRUITING | Relapsed Small Cell Lung Cancer |
Luye Pharma Group Ltd. |
2024-03-03 | PHASE3 |
| NCT06161025 | RECRUITING | Solid Cancer |
Daiichi Sankyo |
2024-02-27 | PHASE2; PHASE3 |
| NCT06203210 | RECRUITING | Small Cell Lung Cancer |
Daiichi Sankyo |
2024-05-21 | PHASE3 |
| NCT06666712 | RECRUITING | Brain Tumor, Recurrent; Malignant Glioma (WHO Grade III or IV); IDH1/IDH2 Mutation |
Jeffrey N. Bruce |
2026-06-12 | PHASE1 |
| NCT06496048 | RECRUITING | Relapsed Small Cell Lung Cancer |
Luye Pharma Group Ltd. |
2024-09-14 | PHASE3 |
| NCT06425419 | NOT_YET_RECRUITING | Proliferative Vitreoretinopathy; Proliferative Vitreo-Retinopathy; Rhegmatogenous Retinal Detachment |
Massachusetts Eye and Ear Infirmary |
2026-09-01 | PHASE1 |
| NCT06612151 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer |
MediLink Therapeutics (Suzhou) Co., Ltd. |
2024-12-17 | PHASE3 |
| NCT07106528 | NOT_YET_RECRUITING | Extensive-stage Small Cell Lung Cancer (ES-SCLC); Extensive-stage Small Cell Lung Cancer (SCLC); Small Cell Lung Cancer ( SCLC ) |
Peking Union Medical College Hospital |
2025-08 | PHASE2; PHASE3 |
| NCT02354547 | SUSPENDED | Neoplasm |
SynerGene Therapeutics, Inc. |
2014-12 | PHASE1 |
| NCT05652686 | RECRUITING | Small Cell Lung Cancer (SCLC); Large Cell Neuroendocrine Cancer (LCNEC); Neuroendocrine Prostate Cancer (NEPC); Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC); Neuroendocrine Carcinomas (NEC); Extrapulmonary Neuroendocrine Carcinoma (EP-NEC) |
Phanes Therapeutics |
2023-09-05 | PHASE1; PHASE2 |
| NCT07418749 | RECRUITING | Recurrent Cervical Cancer; Metastatic Cervical Cancer |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
2026-03-30 | PHASE3 |
| NCT06581380 | NOT_YET_RECRUITING | Small Cell Lung Cancer |
JenKem Technology Co., Ltd. |
2024-09-16 | PHASE3 |
| NCT07099898 | RECRUITING | Neoplasms, Lung |
GlaxoSmithKline |
2025-08-11 | PHASE3 |
| NCT05874401 | RECRUITING | Extensive-stage Small-cell Lung Cancer |
Pharmacosmos A/S |
2023-10-18 | PHASE4 |
| NCT07604766 | RECRUITING | Platinum-resistant Ovarian Cancer |
Genmab |
2026-06-26 | PHASE3 |
| NCT05303727 | NOT_YET_RECRUITING | Neuroblastoma |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
2022-08 | PHASE2 |
| NCT04322318 | RECRUITING | Anaplastic Kidney Wilms Tumor; Recurrent Kidney Wilms Tumor; Stage II Kidney Wilms Tumor; Stage III Kidney Wilms Tumor; Stage IV Kidney Wilms Tumor |
Children's Oncology Group |
2020-10-19 | PHASE2 |
| NCT04947501 | ACTIVE_NOT_RECRUITING | Neuroblastoma; Pediatric Cancer |
Memorial Sloan Kettering Cancer Center |
2021-06-22 | EARLY_PHASE1 |
| NCT06994195 | RECRUITING | Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2025-08-04 | PHASE3 |
| NCT06449209 | ACTIVE_NOT_RECRUITING | Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer |
BioNTech SE |
2024-08-05 | PHASE2 |
| NCT06930755 | RECRUITING | Ovarian Cancer |
Nerviano Medical Sciences |
2026-05-13 | PHASE1 |
| NCT06954246 | RECRUITING | Small Cell Lung Cancer Extensive Stage |
Qilu Pharmaceutical Co., Ltd. |
2025-06-04 | PHASE3 |
| NCT06828354 | RECRUITING | Ovarian Cancer |
Jiangsu HengRui Medicine Co., Ltd. |
2025-03-13 | PHASE3 |
| NCT06818721 | NOT_YET_RECRUITING | Retinal Detachment Rhegmatogenous; Proliferative Vitreoretinopathy |
Unity Health Toronto |
2025-03 | PHASE2 |
| NCT05101551 | RECRUITING | Acute Myeloid Leukemia |
Norman J. Lacayo |
2023-02-23 | PHASE1 |
| NCT05990738 | ACTIVE_NOT_RECRUITING | Small Cell Lung Carcinoma (SCLC) |
Boehringer Ingelheim |
2024-02-14 | PHASE1 |
| NCT06855069 | RECRUITING | Ovarian Cancer |
Hansoh BioMedical R&D Company |
2025-03-13 | PHASE3 |
| NCT06619236 | ACTIVE_NOT_RECRUITING | Platinum-resistant Ovarian Cancer |
Genmab |
2025-02-07 | PHASE3 |
| NCT06616532 | ACTIVE_NOT_RECRUITING | SCLC |
Biotheus Inc. |
2024-11-13 | PHASE3 |
| NCT06751485 | NOT_YET_RECRUITING | Ovarian Cancer; Primary Peritoneal; Fallopian Tube Cancers |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
2025-01-15 | PHASE3 |
| NCT02298348 | ACTIVE_NOT_RECRUITING | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2015-10-08 | PHASE1 |
| NCT04047251 | ACTIVE_NOT_RECRUITING | Advanced Solid Tumors; Merkel Cell Carcinoma |
Fujifilm Pharmaceuticals U.S.A., Inc. |
2019-11-14 | PHASE1 |
| NCT06500026 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2024-08-07 | PHASE3 |
| NCT06498479 | RECRUITING | Small Cell Lung Cancer |
Hansoh BioMedical R&D Company |
2024-07-04 | PHASE3 |
| NCT07145333 | ACTIVE_NOT_RECRUITING | SCLC |
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair |
2025-08-12 | PHASE2; PHASE3 |
| NCT06548763 | NOT_YET_RECRUITING | Endometrial Cancer |
Fudan University |
2024-11-30 | PHASE2 |
| NCT06394492 | RECRUITING | Ovarian Cancer |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
2024-05-10 | PHASE3 |
| NCT05153239 | COMPLETED | Relapsed Small Cell Lung Cancer |
PharmaMar |
2022-07-22 | PHASE3 |
| NCT05353439 | ACTIVE_NOT_RECRUITING | Extensive Stage Lung Small Cell Carcinoma; Limited Stage Lung Small Cell Carcinoma; Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Extensive Stage Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma |
National Cancer Institute (NCI) |
2022-07-27 | PHASE1 |
| NCT05736952 | WITHDRAWN | Platinum-resistant Ovarian Cancer |
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
2023-03-01 | PHASE2 |
| NCT05523869 | RECRUITING | Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment |
Unity Health Toronto |
2023-02-23 | PHASE2 |
| NCT06972602 | RECRUITING | Retinoblastoma; Retinoblastoma, Recurrent |
Eye & ENT Hospital of Fudan University |
2025-04-01 | EARLY_PHASE1 |
| NCT02114229 | ACTIVE_NOT_RECRUITING | Malignant Rhabdoid Tumor; Atypical Teratoid Rhabdoid Tumor |
St. Jude Children's Research Hospital |
2014-05-14 | PHASE2 |
| NCT03600649 | UNKNOWN | Ewing Sarcoma; Myxoid Liposarcoma; Sarcoma,Soft Tissue; Desmoplastic Small Round Cell Tumor; Extraskeletal Myxoid Chondrosarcoma; Angiomatoid Fibrous Histiocytoma; Clear Cell Sarcoma; Primary Pulmonary Myxoid Sarcoma; Myoepithelial Tumor; Sclerosing Epithelioid Fibrosarcoma; Fibromyxoid Tumor |
Salarius Pharmaceuticals, LLC |
2018-06-04 | PHASE1 |
| NCT05870748 | TERMINATED | Ovarian Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Platinum-resistant Ovarian Cancer |
Sutro Biopharma, Inc. |
2023-07-12 | PHASE2; PHASE3 |
| NCT04239092 | TERMINATED | Refractory Cancer; Refractory Neoplasm; Cancer Pediatric; Refractory Tumor; Pediatric Cancer; Pediatric Brain Tumor; Neuroblastoma; Neuroblastoma Recurrent; Pediatric Lymphoma; Pediatric Meningioma; Diffuse Intrinsic Pontine Glioma |
Actuate Therapeutics Inc. |
2020-06-05 | PHASE1 |
| NCT05429502 | TERMINATED | Neuroblastoma |
Novartis Pharmaceuticals |
2022-12-27 | PHASE1 |
| NCT04514497 | ACTIVE_NOT_RECRUITING | Metastatic Lung Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Neuroendocrine Carcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Lung Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Lung Small Cell Carcinoma; Unresectable Malignant Solid Neoplasm; Unresectable Neuroendocrine Carcinoma; Unresectable Pancreatic Adenocarcinoma |
National Cancer Institute (NCI) |
2021-10-20 | PHASE1 |
| NCT05740566 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer (SCLC) |
Amgen |
2023-05-31 | PHASE3 |
| NCT05092360 | TERMINATED | Platinum-resistant Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Mural Oncology, Inc |
2022-01-10 | PHASE3 |
| NCT04679064 | UNKNOWN | Ovarian Cancer |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2020-12-01 | PHASE3 |
| NCT04799002 | RECRUITING | Retinoblastoma; Chemotherapy Effect |
Sun Yat-sen University |
2021-03-11 | PHASE3 |
| NCT04428879 | COMPLETED | Retinoblastoma |
The Hospital for Sick Children |
2020-06-16 | PHASE1 |
| NCT04156347 | UNKNOWN | Retinoblastoma |
Targeted Therapy Technologies, LLC |
2021-06-16 | PHASE1 |
| NCT02584478 | UNKNOWN | Endometrial Carcinoma; Ovarian Carcinoma; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Cervical Carcinoma |
Advenchen Laboratories, LLC |
2015-12 | PHASE3 |
| NCT02419495 | TERMINATED | Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC v8; Pathologic Stage IIIA Cutaneous Melanoma AJCC v8; Pathologic Stage IIIB Cutaneous Melanoma AJCC v8; Pathologic Stage IIIC Cutaneous Melanoma AJCC v8; Pathologic Stage IIID Cutaneous Melanoma AJCC v8; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC v8; Stage III Renal Cell Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma |
M.D. Anderson Cancer Center |
2015-06-26 | PHASE1 |
| NCT03709680 | ACTIVE_NOT_RECRUITING | Ewing Sarcoma; Solid Tumors; Rhabdoid Tumor; Rhabdomyosarcoma; Neuroblastoma; Medulloblastoma; Diffuse Intrinsic Pontine Glioma |
Pfizer |
2019-05-24 | PHASE2 |
| NCT03107988 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2017-09-05 | PHASE1 |
| NCT04994977 | TERMINATED | Atypical Choroid Plexus Papilloma; Choroid Plexus Carcinoma |
Weill Medical College of Cornell University |
2023-05-04 | PHASE1 |
| NCT05613088 | COMPLETED | Neoplasms, Ovarian |
Bristol-Myers Squibb |
2023-02-01 | PHASE2 |
| NCT04029688 | TERMINATED | Acute Myeloid Leukemia (AML); Acute Lymphoblastic Leukemia (ALL); Neuroblastoma; Solid Tumors |
Hoffmann-La Roche |
2020-01-27 | PHASE1; PHASE2 |
| NCT02030964 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2014-01-16 | PHASE1 |
| NCT04908787 | COMPLETED | Ovarian Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2021-06-11 | PHASE3 |
| NCT00657878 | UNKNOWN | Ovarian Cancer |
National Cancer Institute, Naples |
2008-11 | PHASE3 |
| NCT03165292 | TERMINATED | Very High Risk Neuroblastoma |
Gustave Roussy, Cancer Campus, Grand Paris |
2018-10-01 | PHASE2 |
| NCT04697628 | COMPLETED | Cervical Cancer |
Seagen, a wholly owned subsidiary of Pfizer |
2021-02-22 | PHASE3 |
| NCT04768296 | COMPLETED | Small-cell Lung Cancer |
EMD Serono Research & Development Institute, Inc. |
2021-03-29 | PHASE2 |
| NCT05246111 | COMPLETED | Advanced Solid Tumor |
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany |
2022-02-15 | PHASE1 |
| NCT02502266 | ACTIVE_NOT_RECRUITING | Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Ovarian Undifferentiated Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
National Cancer Institute (NCI) |
2016-05-03 | PHASE2; PHASE3 |
| NCT03289910 | ACTIVE_NOT_RECRUITING | Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Atypical Chronic Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Essential Thrombocythemia; Myelodysplastic/Myeloproliferative Neoplasm; Myelofibrosis; Polycythemia Vera; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2018-09-24 | PHASE2 |
| NCT03927274 | TERMINATED | Glioma of Brain |
H. Lee Moffitt Cancer Center and Research Institute |
2019-06-20 | EARLY_PHASE1 |
| NCT04455139 | TERMINATED | Eye Cancer, Retinoblastoma |
Prof. Beck Popovic Maja |
2021-11-15 | PHASE2 |
| NCT02312245 | COMPLETED | Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Mayo Clinic |
2015-07-21 | PHASE2 |
| NCT01783535 | ACTIVE_NOT_RECRUITING | Retinoblastoma |
St. Jude Children's Research Hospital |
2013-06-19 | PHASE2 |
| NCT05295589 | WITHDRAWN | Platinum-Refractory Fallopian Tube Carcinoma; Platinum-Refractory Ovarian Carcinoma; Platinum-Refractory Primary Peritoneal Carcinoma; Recurrent Fallopian Tube Endometrioid Adenocarcinoma; Recurrent Fallopian Tube High Grade Serous Adenocarcinoma; Recurrent Ovarian Endometrioid Adenocarcinoma; Recurrent Ovarian High Grade Serous Adenocarcinoma; Recurrent Platinum-Resistant Fallopian Tube Carcinoma; Recurrent Platinum-Resistant Ovarian Carcinoma; Recurrent Platinum-Resistant Primary Peritoneal Carcinoma; Recurrent Primary Peritoneal Endometrioid Adenocarcinoma; Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma |
National Cancer Institute (NCI) |
2022-06-30 | PHASE2 |
| NCT04209855 | COMPLETED | Epithelial Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer |
AbbVie |
2019-12-31 | PHASE3 |
| NCT03475121 | COMPLETED | Unilateral Retinoblastoma |
Hospital JP Garrahan |
2018-01-01 | PHASE3 |
| NCT04739800 | ACTIVE_NOT_RECRUITING | Fallopian Tube Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Platinum-Refractory Fallopian Tube Carcinoma; Platinum-Refractory Ovarian Carcinoma; Platinum-Refractory Primary Peritoneal Carcinoma; Recurrent Fallopian Tube Clear Cell Adenocarcinoma; Recurrent Fallopian Tube Endometrioid Adenocarcinoma; Recurrent Fallopian Tube High Grade Serous Adenocarcinoma; Recurrent Fallopian Tube Mucinous Adenocarcinoma; Recurrent Fallopian Tube Transitional Cell Carcinoma; Recurrent Fallopian Tube Undifferentiated Carcinoma; Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma; Recurrent Ovarian Clear Cell Adenocarcinoma; Recurrent Ovarian Endometrioid Adenocarcinoma; Recurrent Ovarian High Grade Serous Adenocarcinoma; Recurrent Ovarian Low Grade Serous Adenocarcinoma; Recurrent Ovarian Mucinous Adenocarcinoma; Recurrent Ovarian Seromucinous Carcinoma; Recurrent Ovarian Transitional Cell Carcinoma; Recurrent Ovarian Undifferentiated Carcinoma; Recurrent Platinum-Resistant Fallopian Tube Carcinoma; Recurrent Platinum-Resistant Ovarian Carcinoma; Recurrent Platinum-Resistant Primary Peritoneal Carcinoma; Recurrent Primary Peritoneal Clear Cell Adenocarcinoma; Recurrent Primary Peritoneal Endometrioid Adenocarcinoma; Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Low Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Transitional Cell Carcinoma; Recurrent Primary Peritoneal Undifferentiated Carcinoma; Refractory Fallopian Tube Clear Cell Adenocarcinoma; Refractory Fallopian Tube Endometrioid Adenocarcinoma; Refractory Fallopian Tube High Grade Serous Adenocarcinoma; Refractory Fallopian Tube Mucinous Adenocarcinoma; Refractory Fallopian Tube Transitional Cell Carcinoma; Refractory Fallopian Tube Undifferentiated Carcinoma; Refractory Low Grade Fallopian Tube Serous Adenocarcinoma; Refractory Ovarian Clear Cell Adenocarcinoma; Refractory Ovarian Endometrioid Adenocarcinoma; Refractory Ovarian High Grade Serous Adenocarcinoma; Refractory Ovarian Low Grade Serous Adenocarcinoma; Refractory Ovarian Mucinous Adenocarcinoma; Refractory Ovarian Seromucinous Carcinoma; Refractory Ovarian Transitional Cell Carcinoma; Refractory Ovarian Undifferentiated Carcinoma; Refractory Primary Peritoneal Clear Cell Adenocarcinoma; Refractory Primary Peritoneal Endometrioid Adenocarcinoma; Refractory Primary Peritoneal High Grade Serous Adenocarcinoma; Refractory Primary Peritoneal Low Grade Serous Adenocarcinoma; Refractory Primary Peritoneal Transitional Cell Carcinoma; Refractory Primary Peritoneal Undifferentiated Carcinoma |
National Cancer Institute (NCI) |
2021-06-10 | PHASE2 |
| NCT03896503 | ACTIVE_NOT_RECRUITING | Extensive Stage Lung Small Cell Carcinoma; Extrapulmonary Small Cell Neuroendocrine Carcinoma; Limited Stage Lung Small Cell Carcinoma; Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma |
National Cancer Institute (NCI) |
2019-12-30 | PHASE2 |
| NCT04661852 | COMPLETED | Relapsed Ewing Sarcoma; Refractory Ewing Sarcoma; Relapsed Osteosarcoma; Refractory Osteosarcoma |
Dana-Farber Cancer Institute |
2020-12-23 | PHASE1 |
| NCT04022876 | TERMINATED | Non Small Cell Lung Cancer; Small-cell Lung Cancer |
Aileron Therapeutics, Inc. |
2019-09-03 | PHASE1 |
| NCT02303028 | COMPLETED | Solid Tumors |
The Hospital for Sick Children |
2015-03 | PHASE1; PHASE2 |
| NCT03554473 | COMPLETED | Carcinoma, Small Cell; Lung Cancer; Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2018-09-11 | PHASE1; PHASE2 |
| NCT04106219 | ACTIVE_NOT_RECRUITING | Neuroblastoma |
Eli Lilly and Company |
2020-06-11 | PHASE1 |
| NCT03088813 | COMPLETED | Small Cell Lung Cancer |
Ipsen |
2018-04-25 | PHASE3 |
| NCT02364713 | TERMINATED | Fallopian Tube Carcinosarcoma; Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Carcinosarcoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Ovarian Undifferentiated Carcinoma; Platinum-Resistant Fallopian Tube Carcinoma; Platinum-Resistant Ovarian Carcinoma; Platinum-Resistant Primary Peritoneal Carcinoma; Primary Peritoneal Carcinosarcoma; Primary Peritoneal Clear Cell Adenocarcinoma; Primary Peritoneal Endometrioid Adenocarcinoma; Primary Peritoneal Serous Adenocarcinoma; Primary Peritoneal Transitional Cell Carcinoma; Primary Peritoneal Undifferentiated Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Mayo Clinic |
2015-03-13 | PHASE2 |
| NCT05083000 | UNKNOWN | COVID-19 Respiratory Infection |
National University Hospital, Singapore |
2021-08-16 | PHASE1 |
| NCT03786783 | COMPLETED | Ganglioneuroblastoma; High Risk Neuroblastoma |
National Cancer Institute (NCI) |
2019-03-04 | PHASE2 |
| NCT04902885 | COMPLETED | Extensive-stage Small-cell Lung Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2021-05-25 | PHASE3 |
| NCT01143779 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-06 | PHASE1 |
| NCT02866006 | COMPLETED | Uterine Cervical Neoplasms |
Cellid Co., Ltd. |
2016-10 | PHASE1; PHASE2 |
| NCT04455139 | Terminated | Eye Cancer Retinoblastoma |
Prof. Beck Popovic Maja|University of Lausanne Hospitals |
2021-11-15 | Phase 2 |
| NCT04943627 | WITHDRAWN | Advanced Cancer; Metastatic Cervical Cancer |
Agenus Inc. |
2021-08-02 | PHASE3 |
| NCT01857934 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
2013-07-05 | PHASE2 |
| NCT03154996 | COMPLETED | Gliomas |
Columbia University |
2018-01-18 | PHASE1 |
| NCT02308527 | COMPLETED | Neuroblastoma |
University of Birmingham |
2013-07 | PHASE2 |
| NCT05083000 | Unknown status | COVID-19 Respiratory Infection |
National University Hospital Singapore|Christian Medical College Vellore India |
2021-08-16 | Phase 1 |
| NCT04213937 | UNKNOWN | Extensive Stage Small Cell Lung Cancer |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2020-01-31 | PHASE2 |
| NCT04073550 | UNKNOWN | Small Cell Lung Cancer |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
2019-10-31 | PHASE3 |
| NCT02649673 | TERMINATED | Small Cell Lung Cancer; Ovarian Cancer |
SCRI Development Innovations, LLC |
2016-03-23 | PHASE1 |
| NCT02822157 | UNKNOWN | Ovarian Epithelial Cancer |
Universitaire Ziekenhuizen KU Leuven |
2016-08 | PHASE2 |
| NCT04156347 | Active not recruiting | Retinoblastoma |
Targeted Therapy Technologies LLC |
2021-06-16 | Phase 1 |
| NCT03227016 | UNKNOWN | Small Cell Lung Cancer SCLC |
Central European Society for Anticancer Drug Research |
2016-10 | PHASE1 |
| NCT02487095 | COMPLETED | Carcinoma, Non-Small -Cell Lung; Ovarian Neoplasms; Small Cell Lung Carcinoma; Uterine Cervical Neoplasms; Carcinoma, Neuroendocrine; Extrapulmonary Small Cell Cancer |
National Cancer Institute (NCI) |
2015-07-30 | PHASE1; PHASE2 |
| NCT03987685 | COMPLETED | Solid Tumor |
Athenex, Inc. |
2018-07-19 | PHASE1 |
| NCT00317772 | COMPLETED | Ovarian Cancer; Peritoneal Neoplasms; Fallopian Tube Cancer |
M.D. Anderson Cancer Center |
2004-09-02 | PHASE1; PHASE2 |
| NCT04428879 | Recruiting | Retinoblastoma |
The Hospital for Sick Children |
2020-06-16 | Phase 1 |
| NCT00601003 | COMPLETED | Neuroblastoma; Medulloblastoma |
Giselle Sholler |
2008-01-14 | PHASE2 |
| NCT01231906 | COMPLETED | Localized Extraskeletal Ewing Sarcoma; Peripheral Primitive Neuroectodermal Tumor of Bone; Peripheral Primitive Neuroectodermal Tumor of Soft Tissues |
Children's Oncology Group |
2010-11-24 | PHASE3 |
| NCT02866370 | UNKNOWN | Ovarian Clear Cell Carcinoma; Endometrial Clear Cell Carcinoma |
NHS Greater Glasgow and Clyde |
2015-04 | PHASE2 |
| NCT02566993 | COMPLETED | Small-cell Lung Cancer |
PharmaMar |
2016-08-30 | PHASE3 |
| NCT03061812 | COMPLETED | Small Cell Lung Cancer |
AbbVie |
2017-04-11 | PHASE3 |
| NCT03098030 | COMPLETED | Small Cell Lung Cancer |
United Therapeutics |
2017-06-01 | PHASE2; PHASE3 |
| NCT03763123 | UNKNOWN | Ovarian Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2018-04-24 | PHASE1 |
| NCT02684071 | TERMINATED | Recurrent Childhood Medulloblastoma; Recurrent Childhood Ependymoma; Childhood Atypical Teratoid/Rhabdoid Tumor; Embryonal Tumor With Abundant Neuropil and True Rosettes; Metastatic Malignant Neoplasm to the Leptomeninges |
Nicklaus Children's Hospital f/k/a Miami Children's Hospital |
2016-02 | PHASE2 |
| NCT02390843 | COMPLETED | Retinoblastoma; Clear Cell Sarcoma; Renal Cell Carcinoma; Rhabdoid Tumor; Wilms Tumor; Hepatoblastoma; Neuroblastoma; Germ Cell Tumors; Ewings Sarcoma; Non-rhabdomyosarcoma Soft Tissue Sarcoma; Osteosarcoma; Rhabdomyosarcoma |
Emory University |
2015-02 | PHASE1 |
| NCT01931098 | COMPLETED | Glioblastoma; Glioblastoma Multiforme; Gliosarcoma; Brain Neoplasms; Central Nervous System Neoplasms |
National Cancer Institute (NCI) |
2015-12-10 | PHASE2 |
| NCT02348398 | WITHDRAWN | Cervical Cancer |
M.D. Anderson Cancer Center |
2016-08 | PHASE2 |
| NCT02963090 | TERMINATED | Small Cell Lung Cancer |
Alliance Foundation Trials, LLC. |
2017-05-20 | PHASE2 |
| NCT02030184 | WITHDRAWN | Small Cell Lung Cancer (SCLC); Neuroendocrine (NE) Tumors; Large Cell Neuroendocrine (NE) Tumors |
University of Maryland, Baltimore |
2017-06 | PHASE1; PHASE2 |
| NCT02101788 | COMPLETED | Borderline Ovarian Serous Tumor; Micropapillary Serous Carcinoma; Ovarian Serous Adenocarcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Ovarian Low Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Serous Adenocarcinoma |
National Cancer Institute (NCI) |
2014-04-11 | PHASE2; PHASE3 |
| NCT02980809 | UNKNOWN | Small Cell Lung Cancer |
First Hospitals affiliated to the China PLA General Hospital |
2017-03 | PHASE2 |
| NCT02786719 | COMPLETED | Neuroblastoma |
Baylor College of Medicine |
2016-06 | |
| NCT01012817 | ACTIVE_NOT_RECRUITING | Metastatic Malignant Solid Neoplasm; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Unresectable Solid Neoplasm |
National Cancer Institute (NCI) |
2009-11-03 | PHASE1; PHASE2 |
| NCT00877110 | COMPLETED | Neuroblastoma; Bone Marrow, Sympathetic Nervous System |
Memorial Sloan Kettering Cancer Center |
2009-04-02 | PHASE1 |
| NCT02631876 | COMPLETED | Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer; Ovarian Cancer |
ImmunoGen, Inc. |
2016-03-02 | PHASE3 |
| NCT01606878 | COMPLETED | Childhood Solid Neoplasm; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Neuroblastoma |
Children's Oncology Group |
2013-04-29 | PHASE1 |
| NCT02903004 | COMPLETED | Ovarian Neoplasms |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2016-04-11 | PHASE3 |
| NCT03193463 | WITHDRAWN | Glioma |
Michael Vogelbaum, MD, PhD |
2017-11-03 | EARLY_PHASE1 |
| NCT02500459 | TERMINATED | Brain Tumor; High Grade Glioma |
Michael Vogelbaum, MD, PhD |
2015-07-06 | EARLY_PHASE1 |
| NCT01492673 | COMPLETED | Neuroblastoma; Sarcoma |
Memorial Sloan Kettering Cancer Center |
2011-12 | PHASE2 |
| NCT02421588 | COMPLETED | Ovarian Cancer |
PharmaMar |
2015-05 | PHASE3 |
| NCT02514447 | COMPLETED | Small Cell Lung Cancer |
G1 Therapeutics, Inc. |
2015-10-05 | PHASE1; PHASE2 |
| NCT03059667 | COMPLETED | Small Cell Lung Cancer; Small Cell Lung Cancer Limited Stage; Small Cell Lung Cancer Extensive Stage |
Intergroupe Francophone de Cancerologie Thoracique |
2017-03-13 | PHASE2 |
| NCT02481830 | COMPLETED | Lung Cancer |
Bristol-Myers Squibb |
2015-09-14 | PHASE3 |
| NCT02357810 | COMPLETED | Adult Liposarcoma; Metastatic Liposarcoma; Metastatic Osteosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Liposarcoma; Recurrent Osteosarcoma; Stage IV Adult Soft Tissue Sarcoma |
Northwestern University |
2015-03-21 | PHASE2 |
| NCT01654965 | COMPLETED | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2012-07-24 | PHASE1 |
| NCT01795430 | WITHDRAWN | Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor |
City of Hope Medical Center |
2013-07 | |
| NCT00856037 | COMPLETED | Recurrent Small Cell Lung Carcinoma |
University of Nebraska |
2009-02-02 | PHASE1 |
| NCT01497873 | COMPLETED | Small Cell Lung Cancer |
Chong Kun Dang Pharmaceutical |
2010-09 | PHASE2 |
| NCT02738346 | UNKNOWN | Small Cell Lung Cancer |
University Hospital, Angers |
2013-07 | PHASE3 |
| NCT02200757 | COMPLETED | Metastatic Small Cell Lung Cancer |
ImmunityBio, Inc. |
2015-04-20 | PHASE2 |
| NCT01600573 | UNKNOWN | Ovarian Cancer |
JSehouli |
2012-05 | PHASE1; PHASE2 |
| NCT00526318 | UNKNOWN | Neuroblastoma |
German Society for Pediatric Oncology and Hematology GPOH gGmbH |
2007-01 | |
| NCT00588991 | COMPLETED | Adult Acute Megakaryoblastic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Adult Erythroleukemia; Adult Pure Erythroid Leukemia; Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; De Novo Myelodysplastic Syndrome; Essential Thrombocythemia; Hematopoietic and Lymphoid Cell Neoplasm; Myelodysplastic Syndrome; Polycythemia Vera; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome |
National Cancer Institute (NCI) |
2008-02-04 | PHASE1 |
| NCT01175356 | COMPLETED | Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2011-12-21 | PHASE1 |
| NCT01670175 | COMPLETED | Malignant Solid Tumor; Childhood Solid Tumor |
University of California, San Francisco |
2012-08 | PHASE1 |
| NCT01593228 | COMPLETED | Solid Tumors |
Sanofi |
2012-05 | PHASE3 |
| NCT01696032 | COMPLETED | Ovarian Cancer |
Astex Pharmaceuticals, Inc. |
2012-09 | PHASE2 |
| NCT02107378 | TERMINATED | Epithelial Ovarian Carcinoma |
SOTIO a.s. |
2014-01 | PHASE2 |
| NCT02569957 | TERMINATED | Malignant Ovarian Endometrioid Tumor; Malignant Ovarian Serous Tumor; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2015-10-02 | PHASE2 |
| NCT01417806 | UNKNOWN | Small Cell Lung Cancer |
South Florida Veterans Affairs Foundation for Research and Education |
2011-07 | PHASE2 |
| NCT00960739 | COMPLETED | Neuroblastoma |
Centre Oscar Lambret |
2008-11 | PHASE2 |
| NCT01803269 | TERMINATED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
University of Chicago |
2013-01-16 | PHASE2 |
| NCT01266447 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage III Cervical Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2011-02 | PHASE2 |
| NCT02100007 | TERMINATED | Solid Tumors |
MEI Pharma, Inc. |
2014-04 | PHASE1; PHASE2 |
| NCT01683149 | COMPLETED | Solid Tumor |
H. Lee Moffitt Cancer Center and Research Institute |
2013-01 | PHASE1 |
| NCT02278510 | COMPLETED | Malignant Glioma; WHO Grade III or IV Recurrent Glioma |
Michael Vogelbaum, MD, PhD |
2014-12-09 | EARLY_PHASE1 |
| NCT01466855 | TERMINATED | Retinoblastoma |
Children's Hospital Medical Center, Cincinnati |
2011-10 | EARLY_PHASE1 |
| NCT01798004 | COMPLETED | Ganglioneuroblastoma; Stage 1 Neuroblastoma; Stage 2 Neuroblastoma; Stage 2A Neuroblastoma; Stage 2B Neuroblastoma; Stage 3 Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2013-04-09 | PHASE1 |
| NCT00800345 | COMPLETED | Gynecologic Tumors |
Vector Oncology |
2009-04 | PHASE1 |
| NCT00308165 | COMPLETED | Brain Neoplasms, Primary Malignant |
Columbia University |
2004-03 | PHASE1 |
| NCT00567567 | COMPLETED | Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2007-11-05 | PHASE3 |
| NCT01047891 | COMPLETED | Ovarian Cancer |
JSehouli |
2010-01 | PHASE2 |
| NCT01684878 | COMPLETED | Ovarian Cancer |
Hoffmann-La Roche |
2012-10-22 | PHASE3 |
| NCT01690598 | COMPLETED | Ovarian Cancer |
Vejle Hospital |
2012-11 | PHASE1; PHASE2 |
| NCT01533181 | COMPLETED | Recurrent Small Cell Lung Carcinoma |
National Cancer Institute (NCI) |
2012-02 | PHASE2 |
| NCT01736800 | WITHDRAWN | Central Nervous System (CNS) Metastases; Brain Metastases |
The Methodist Hospital Research Institute |
2007-03 | PHASE2 |
| NCT00550784 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
City of Hope Medical Center |
2001-01 | PHASE1 |
| NCT00634244 | COMPLETED | Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2008-10 | PHASE2 |
| NCT00976911 | COMPLETED | Ovarian Cancer |
Hoffmann-La Roche |
2009-10-29 | PHASE3 |
| NCT00499616 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2007-10-08 | PHASE3 |
| NCT01904253 | TERMINATED | Small Cell Lung Cancer (SCLC) |
Taiho Oncology, Inc. |
2013-07 | PHASE2 |
| NCT01121406 | COMPLETED | Ovarian Neoplasms |
Boehringer Ingelheim |
2010-04 | PHASE2 |
| NCT01630018 | COMPLETED | Epithelial Ovarian Cancer |
Chong Kun Dang Pharmaceutical |
2011-01 | PHASE2 |
| NCT01840943 | TERMINATED | Epithelial Ovarian Cancer |
Xian-Janssen Pharmaceutical Ltd. |
2013-06 | PHASE3 |
| NCT01500720 | COMPLETED | Small Cell Lung Cancer |
Sanofi |
2012-03 | PHASE2 |
| NCT00812266 | TERMINATED | Extensive Disease; First-Line; Small Cell Lung Cancer |
Danish Oncological Lung Cancer Group |
2006-01 | PHASE3 |
| NCT00186888 | COMPLETED | Retinoblastoma; Retinal Neoplasm |
St. Jude Children's Research Hospital |
2005-04-07 | PHASE3 |
| NCT00462787 | COMPLETED | Leukemia |
Memorial Sloan Kettering Cancer Center |
2007-04 | PHASE1 |
| NCT00918320 | COMPLETED | Neuroblastoma; Brain Tumors; Solid Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
2009-06 | PHASE2 |
| NCT00325416 | COMPLETED | Multiple Myeloma |
H. Lee Moffitt Cancer Center and Research Institute |
2001-11-19 | PHASE1; PHASE2 |
| NCT00437307 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2007-03 | PHASE3 |
| NCT00732420 | COMPLETED | Solid Tumours |
GlaxoSmithKline |
2008-09-24 | PHASE1 |
| NCT00477282 | COMPLETED | Ovarian Cancer |
BioNumerik Pharmaceuticals, Inc. |
2007-08 | PHASE3 |
| NCT00045175 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
University Health Network, Toronto |
2002-06 | PHASE1 |
| NCT00803062 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2009-04 | PHASE3 |
| NCT00638898 | COMPLETED | Solid Tumor; Adult Central Nervous System Germ Cell Tumor; Adult Rhabdomyosarcoma; Childhood Central Nervous System Germ Cell Tumor; Childhood Soft Tissue Sarcoma; Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Ovarian Mixed Germ Cell Tumor; Previously Untreated Childhood Rhabdomyosarcoma; Recurrent Adult Brain Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Extragonadal Germ Cell Tumor; Recurrent Extragonadal Non-seminomatous Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Neuroblastoma; Recurrent Ovarian Germ Cell Tumor; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2007-02-26 | PHASE1 |
| NCT00170677 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2005-09 | PHASE2 |
| NCT01017809 | WITHDRAWN | Ovarian Cancer |
NYU Langone Health |
2010-12 | |
| NCT00548418 | COMPLETED | Cervical Cancer |
Washington University School of Medicine |
2007-02 | PHASE2 |
| NCT00770731 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2008-09 | PHASE1 |
| NCT01003938 | TERMINATED | Ovarian Cancer |
NYU Langone Health |
2009-08 | PHASE2 |
| NCT00828139 | COMPLETED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2009-05 | PHASE2 |
| NCT01004874 | COMPLETED | Malignant Glioma; Glioblastoma; Gliosarcoma |
Duke University |
2009-12-30 | PHASE2 |
| NCT00390806 | COMPLETED | Lung Cancer, Non-Small Cell |
GlaxoSmithKline |
2006-12 | PHASE3 |
| NCT01405235 | UNKNOWN | Recurrent, Persistent or Metastasized Cervical Cancer |
Institut fuer Frauengesundheit |
2006-09 | PHASE3 |
| NCT01177501 | TERMINATED | Ovarian Cancer; Relapses |
Assistance Publique - Hôpitaux de Paris |
2009-04 | PHASE1 |
| NCT00980551 | WITHDRAWN | Retinoblastoma |
Children's Hospital Medical Center, Cincinnati |
2010-05 | |
| NCT00483860 | COMPLETED | Solid Tumours |
GlaxoSmithKline |
2007-06-20 | PHASE1 |
| NCT00054444 | COMPLETED | Cervical Adenocarcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer |
Gynecologic Oncology Group |
2007-09 | PHASE1 |
| NCT00770536 | COMPLETED | Cancer; Carcinoma; Fallopian Tube Cancer; Gynecological Malignancies; Metastases; Oncology; Ovarian Cancer; Solid Tumors; Tumors |
Amgen |
2009-01 | PHASE1 |
| NCT00057837 | COMPLETED | Extensive Stage Small Cell Lung Cancer |
Eastern Cooperative Oncology Group |
2004-07-14 | PHASE2 |
| NCT00365547 | COMPLETED | Lung Cancer |
Masonic Cancer Center, University of Minnesota |
2006-09 | PHASE2 |
| NCT00429559 | COMPLETED | Ovarian Cancer |
Hellenic Oncology Research Group |
2006-06 | PHASE1; PHASE2 |
| NCT01076400 | TERMINATED | Cervical Cancer |
Merck Sharp & Dohme LLC |
2010-05-31 | PHASE1; PHASE2 |
| NCT00541359 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2004-01 | PHASE1 |
| NCT00547651 | COMPLETED | Small Cell Lung Cancer |
Celgene |
2007-09-01 | PHASE3 |
| NCT00379457 | UNKNOWN | Sarcoma |
European Paediatric Soft Tissue Sarcoma Study Group |
2006-06 | PHASE3 |
| NCT00807079 | COMPLETED | Cervical Cancer |
ARCAGY/ GINECO GROUP |
2008-09 | PHASE1; PHASE2 |
| NCT00313612 | TERMINATED | Recurrent Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
2006-01 | PHASE2 |
| NCT00842452 | COMPLETED | Cervical Cancer; Endometrial Cancer; Fallopian Tube Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer |
Steven Waggoner, MD |
2009-02 | PHASE1 |
| NCT00382733 | COMPLETED | Tumors |
Accelerated Community Oncology Research Network |
2006-11 | PHASE1; PHASE2 |
| NCT00682279 | WITHDRAWN | Advanced Solid Tumors |
GlaxoSmithKline |
2008-09 | PHASE1 |
| NCT00114166 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2005-01 | PHASE2 |
| NCT00064077 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage IVB Cervical Cancer |
Gynecologic Oncology Group |
2003-05 | PHASE3 |
| NCT00410631 | UNKNOWN | Neuroblastoma |
German Society for Pediatric Oncology and Hematology GPOH gGmbH |
2004-10 | PHASE3 |
| NCT00744081 | COMPLETED | AML |
Goethe University |
2004-07 | PHASE2 |
| NCT00117013 | COMPLETED | Neoplasms |
National Cancer Institute (NCI) |
2005-06-28 | PHASE1 |
| NCT00521144 | COMPLETED | Recurrent Small Cell Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2007-08 | PHASE1; PHASE2 |
| NCT00674674 | COMPLETED | Neoplastic Meningitis |
Baylor College of Medicine |
2005-10 | PHASE1 |
| NCT00112619 | TERMINATED | Brain and Central Nervous System Tumors; Carcinoma of Unknown Primary; Leukemia; Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific |
Pediatric Brain Tumor Consortium |
2005-08 | PHASE1 |
| NCT00765973 | COMPLETED | Small Cell Lung Cancer; Ovarian Cancer; Solid Tumors |
Spectrum Pharmaceuticals, Inc |
2008-11-10 | PHASE1 |
| NCT00098956 | COMPLETED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2005-01 | PHASE2 |
| NCT00698516 | COMPLETED | Recurrent Small-cell Lung Cancer (SCLC); Lung Cancer, Small Cell |
GlaxoSmithKline |
2008-07 | PHASE2 |
| NCT00703807 | COMPLETED | Endometrial Cancer |
Yale University |
2008-12 | PHASE1 |
| NCT00618813 | COMPLETED | Ewing Sarcoma of Bone; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor |
Children's Oncology Group |
2008-03 | |
| NCT00011986 | COMPLETED | Primary Peritoneal Carcinoma; Stage III Ovarian Cancer; Stage IV Ovarian Cancer |
Gynecologic Oncology Group |
2001-01 | PHASE3 |
| NCT00087126 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
2005-02 | PHASE2 |
| NCT00826891 | UNKNOWN | Cervical Cancer |
Chinese Anti-Cancer Association |
2009-02 | PHASE2 |
| NCT00526799 | TERMINATED | Ovarian Cancer |
Daniela Matei, MD |
2007-09 | PHASE1; PHASE2 |
| NCT00343044 | COMPLETED | Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer |
Benaroya Research Institute |
2006-06 | PHASE2 |
| NCT00287963 | COMPLETED | Lung Cancer |
Medical University of South Carolina |
2004-02 | PHASE1 |
| NCT00502892 | COMPLETED | Solid Tumors |
M.D. Anderson Cancer Center |
2004-08 | PHASE1 |
| NCT00392340 | UNKNOWN | Neuroblastoma |
Children's Cancer and Leukaemia Group |
2008-03 | PHASE2 |
| NCT00881166 | COMPLETED | Malignant Disease |
Astex Pharmaceuticals, Inc. |
2007-11 | PHASE1 |
| NCT00287911 | COMPLETED | Cervical Cancer |
Masonic Cancer Center, University of Minnesota |
2005-02 | PHASE1 |
| NCT00466232 | COMPLETED | Small Cell Carcinoma; Lung Cancer |
HealthPartners Institute |
2007-04 | PHASE1 |
| NCT00253461 | TERMINATED | Lung Cancer; Metastatic Cancer; Ovarian Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Case Comprehensive Cancer Center |
2004-12 | EARLY_PHASE1 |
| NCT00322751 | COMPLETED | Lung Cancer |
University of New Mexico |
2006-04 | PHASE1 |
| NCT00720096 | TERMINATED | Ovarian Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2008-07 | |
| NCT00610571 | COMPLETED | Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma |
Katy Peters |
2004-04 | PHASE1 |
| NCT00523432 | COMPLETED | Genital Neoplasms, Female |
University of Chicago |
2007-08 | PHASE1 |
| NCT00697476 | TERMINATED | Small Cell Lung Cancer |
Armando Santoro, MD |
2009-01 | PHASE1; PHASE2 |
| NCT00516295 | COMPLETED | Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor |
National Cancer Institute (NCI) |
2008-02 | PHASE2 |
| NCT00611468 | COMPLETED | Metastatic Solid Tumor |
Accelerated Community Oncology Research Network |
2006-06 | PHASE1 |
| NCT00808899 | TERMINATED | Neuroblastoma |
St. Jude Children's Research Hospital |
2008-12 | PHASE2 |
| NCT00305942 | COMPLETED | Carcinoma, Small Cell |
SCRI Development Innovations, LLC |
2006-03 | PHASE2 |
| NCT00316186 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2005-06 | PHASE2 |
| NCT00436644 | COMPLETED | Ovarian Cancer; Peritoneal Cavity Cancer |
Mayo Clinic |
2007-03 | PHASE2 |
| NCT00516438 | COMPLETED | Malignant Solid Tumors |
AstraZeneca |
2007-07 | PHASE1 |
| NCT00437073 | TERMINATED | Neoplasms, Breast |
GlaxoSmithKline |
2007-05 | PHASE2 |
| NCT00316173 | COMPLETED | Ovarian Cancer; Neoplasms, Ovarian |
GlaxoSmithKline |
2005-03 | PHASE2 |
| NCT00422682 | COMPLETED | Tumors |
Sanofi |
2007-01 | PHASE1 |
| NCT00397293 | COMPLETED | Small Cell Lung Cancer |
Ascenta Therapeutics |
2006-11 | PHASE1; PHASE2 |
| NCT00319969 | COMPLETED | Small Cell Lung Cancer |
Celgene Corporation |
2006-04 | PHASE2 |
| NCT00389766 | WITHDRAWN | Neuroblastoma |
Children's Cancer and Leukaemia Group |
2008-07 | PHASE2 |
| NCT00315861 | COMPLETED | Ovarian Cancer; Endometrial Cancer; Cervical Cancer; Lung Cancer |
SCRI Development Innovations, LLC |
2006-03 | PHASE1 |
| NCT00327171 | COMPLETED | Neoplasms; Cancer of the Ovary |
Sanofi |
2006-05 | PHASE2 |
| NCT00028743 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
NCIC Clinical Trials Group |
2001-08-31 | PHASE3 |
| NCT00553189 | COMPLETED | Solid Tumors; Lymphomas |
National Cancer Institute (NCI) |
2007-08-09 | PHASE1 |
| NCT00215956 | COMPLETED | Rectal Neoplasms |
H. Lee Moffitt Cancer Center and Research Institute |
2001-11 | PHASE1 |
| NCT00257816 | COMPLETED | Cervical Cancer |
University of California, Irvine |
2004-01 | PHASE2 |
| NCT00460876 | COMPLETED | Retinoblastoma |
Hospital JP Garrahan |
2007-03 | PHASE1 |
| NCT00267488 | COMPLETED | Neoplasms, Endometrial; Endometrial Cancer |
GlaxoSmithKline |
2005-10 | PHASE2 |
| NCT00130858 | COMPLETED | Sarcoma, Soft Tissue |
Cooperative Weichteilsarkom Study Group |
2005-01 | PHASE2 |
| NCT00388089 | COMPLETED | Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
University of California, Davis |
2004-12 | PHASE1 |
| NCT00541138 | COMPLETED | Brain and Central Nervous System Tumors; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2003-05 | PHASE2 |
| NCT00004188 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2001-02 | PHASE3 |
| NCT00107471 | TERMINATED | Brain Tumors; Central Nervous System Tumors |
Children's Oncology Group |
2005-10 | PHASE1; PHASE2 |
| NCT00003958 | COMPLETED | Adult Malignant Mesenchymoma; Adult Rhabdomyosarcoma; Alveolar Childhood Rhabdomyosarcoma; Childhood Malignant Mesenchymoma; Embryonal Childhood Rhabdomyosarcoma; Embryonal-botryoid Childhood Rhabdomyosarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma |
Children's Oncology Group |
2002-09 | PHASE3 |
| NCT00294190 | COMPLETED | Small Cell Lung Cancer; Carcinoma, Small Cell |
SCRI Development Innovations, LLC |
2006-02 | PHASE2 |
| NCT00065182 | COMPLETED | Lung Cancer, Non-Small Cell; Non-Small-Cell Lung Cancer |
GlaxoSmithKline |
2003-08-14 | PHASE2 |
| NCT00361803 | COMPLETED | Cancer |
GlaxoSmithKline |
2006-09-12 | PHASE1 |
| NCT00259935 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2004-10-04 | PHASE1 |
| NCT00518193 | TERMINATED | Cervix Cancer |
ARCAGY/ GINECO GROUP |
2007-04 | PHASE2 |
| NCT00002913 | COMPLETED | Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mixed Epithelial Carcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Undifferentiated Adenocarcinoma; Stage III Ovarian Epithelial Cancer; Stage IV Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
1996-12 | PHASE1 |
| NCT00315211 | TERMINATED | Mediastinal Neoplasms |
Aultman Health Foundation |
2004-11 | PHASE2 |
| NCT00135135 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
2005-08 | PHASE2 |
| NCT00003211 | COMPLETED | Brain and Central Nervous System Tumors |
St. Jude Children's Research Hospital |
1996-10 | PHASE2 |
| NCT00320359 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2002-08 | PHASE3 |
| NCT00628732 | COMPLETED | Solid Tumors |
Children's Medical Center Dallas |
2005-01 | PHASE2 |
| NCT00005026 | COMPLETED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2000-02 | PHASE1 |
| NCT00033696 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
2001-09 | PHASE2 |
| NCT00040872 | COMPLETED | Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2000-06 | PHASE2 |
| NCT00003945 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
1999-06 | PHASE3 |
| NCT00053287 | COMPLETED | Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases |
Case Comprehensive Cancer Center |
2002-09 | PHASE2 |
| NCT00276796 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
PHASE2 | |
| NCT00287859 | TERMINATED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Masonic Cancer Center, University of Minnesota |
2004-08 | PHASE1 |
| NCT00057720 | COMPLETED | Ovarian Neoplasms |
Telik |
2003-06 | PHASE3 |
| NCT00003255 | COMPLETED | Leukemia |
Alliance for Clinical Trials in Oncology |
1999-11 | PHASE2 |
| NCT00006373 | COMPLETED | Lymphoma |
H. Lee Moffitt Cancer Center and Research Institute |
2000-02 | PHASE2 |
| NCT00070200 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2004-03 | PHASE1 |
| NCT00005990 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
NYU Langone Health |
2000-08 | PHASE1 |
| NCT00158886 | TERMINATED | Carcinoma, Renal Cell |
GlaxoSmithKline |
2001-11-08 | PHASE1 |
| NCT00006125 | COMPLETED | Lymphoma |
Alliance for Clinical Trials in Oncology |
2000-07 | PHASE2 |
| NCT00006454 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer |
AGO Study Group |
1999-12 | PHASE3 |
| NCT00005792 | COMPLETED | Multiple Myeloma; Plasma Cell Neoplasm |
H. Lee Moffitt Cancer Center and Research Institute |
1998-06-02 | PHASE1 |
| NCT00005793 | COMPLETED | Leukemia |
H. Lee Moffitt Cancer Center and Research Institute |
1999-07 | PHASE1; PHASE2 |
| NCT00109798 | WITHDRAWN | Central Nervous System Tumors; Lymphoma |
The Methodist Hospital Research Institute |
2005-03 | |
| NCT01039025 | COMPLETED | Myeloma |
M.D. Anderson Cancer Center |
2002-02-18 | PHASE2 |
| NCT00097019 | COMPLETED | Ovarian Cancer |
Genentech, Inc. |
2005-02 | PHASE2 |
| NCT00006012 | COMPLETED | Drug/Agent Toxicity by Tissue/Organ; Lung Cancer; Radiation Toxicity |
Alliance for Clinical Trials in Oncology |
2001-02 | PHASE1; PHASE2 |
| NCT00003382 | TERMINATED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
1998-05 | PHASE1 |
| NCT00002693 | COMPLETED | Leukemia; Neutropenia |
Mayo Clinic |
1995-10 | PHASE1 |
| NCT00193167 | COMPLETED | Colon Cancer |
SCRI Development Innovations, LLC |
2004-01 | PHASE2 |
| NCT00005811 | COMPLETED | AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; HIV-associated Hodgkin Lymphoma; Leptomeningeal Metastases; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2000-04 | PHASE2 |
| NCT00003967 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
1999-09 | PHASE1 |
| NCT00252889 | COMPLETED | Small Cell Lung Cancer; Pancreatic Cancer; Head and Neck Cancer; Gastric Cancer; Esophageal Cancer |
Christiana Care Health Services |
2004-05 | PHASE1 |
| NCT00003281 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1998-04 | PHASE2 |
| NCT00002537 | COMPLETED | Lung Cancer |
National Cancer Institute (NCI) |
1993-09 | PHASE1 |
| NCT00068484 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2003-07 | PHASE1 |
| NCT00217555 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Fred Hutchinson Cancer Center |
2002-07 | PHASE2 |
| NCT00087048 | TERMINATED | Lung Cancer |
Case Comprehensive Cancer Center |
2004-04 | PHASE2 |
| NCT00334867 | WITHDRAWN | Sarcoma |
Children's Oncology Group |
2005-12 | PHASE3 |
| NCT00028925 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
2001-11 | PHASE2 |
| NCT00043862 | COMPLETED | Lung Cancer, Small Cell; Small Cell Lung Cancer |
GlaxoSmithKline |
2002-08 | PHASE2 |
| NCT00005962 | COMPLETED | Leukemia |
Eastern Cooperative Oncology Group |
2000-10-04 | PHASE2 |
| NCT00193245 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2000-11 | PHASE2 |
| NCT00003156 | TERMINATED | Sarcoma |
Gynecologic Oncology Group |
1998-06 | PHASE2 |
| NCT00004006 | COMPLETED | Retinoblastoma |
St. Jude Children's Research Hospital |
1997-11 | PHASE2 |
| NCT00170625 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2004-06 | PHASE1; PHASE2 |
| NCT00250094 | COMPLETED | Ovarian Cancer |
New Mexico Cancer Research Alliance |
2004-05 | PHASE1 |
| NCT00193297 | COMPLETED | Ovary Cancer |
SCRI Development Innovations, LLC |
2002-02 | PHASE2 |
| NCT00113789 | COMPLETED | Ovarian Cancer |
Amgen |
2003-10 | PHASE2 |
| NCT00002515 | COMPLETED | Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Head and Neck Cancer; Kidney Cancer; Liver Cancer; Lymphoma; Neuroblastoma; Ovarian Cancer; Retinoblastoma; Sarcoma; Testicular Germ Cell Tumor |
Memorial Sloan Kettering Cancer Center |
1992-10 | PHASE2 |
| NCT00072267 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
University Health Network, Toronto |
2004-01 | PHASE2 |
| NCT00025272 | COMPLETED | Lung Cancer |
Wake Forest University Health Sciences |
2001-11-01 | PHASE2 |
| NCT00004186 | COMPLETED | Lung Cancer |
University of Alabama at Birmingham |
1996-12 | PHASE1; PHASE2 |
| NCT00193388 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2002-09 | PHASE2 |
| NCT00006391 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
NYU Langone Health |
2000-08 | PHASE1 |
| NCT00084565 | WITHDRAWN | Prostate Cancer |
Fox Chase Cancer Center |
2003-11 | PHASE2 |
| NCT00061308 | COMPLETED | Peritoneal Cancer; Ovarian Cancer; Neoplasms, Ovarian; Fallopian Tube Cancer |
GlaxoSmithKline |
2002-12 | PHASE2 |
| NCT00193570 | COMPLETED | Cancer |
SCRI Development Innovations, LLC |
2002-02 | PHASE1 |
| NCT00004055 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1999-11 | PHASE2 |
| NCT00193401 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2002-08 | PHASE2 |
| NCT00003812 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1999-03 | PHASE2 |
| NCT00320983 | COMPLETED | Cervical Cancer |
University of New Mexico |
2002-03 | PHASE1 |
| NCT00002986 | COMPLETED | Brain and Central Nervous System Tumors |
Duke University |
1997-02 | PHASE1 |
| NCT00193583 | COMPLETED | Cancer |
SCRI Development Innovations, LLC |
2003-05 | PHASE1 |
| NCT00038545 | COMPLETED | Non-Hodgkin's Lymphoma |
M.D. Anderson Cancer Center |
2001-05-18 | PHASE2 |
| NCT00046111 | COMPLETED | Lung Cancer, Small Cell; Solid Tumor Cancer |
GlaxoSmithKline |
2001-09 | PHASE1 |
| NCT00049998 | COMPLETED | Non-Small-Cell Lung Cancer |
GlaxoSmithKline |
2001-10 | PHASE3 |
| NCT00004137 | COMPLETED | Lung Cancer |
SWOG Cancer Research Network |
1999-10 | PHASE2 |
| NCT00005612 | TERMINATED | Ovarian Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
1999-08 | PHASE1; PHASE2 |
| NCT00043927 | COMPLETED | Small Cell Lung Cancer |
GlaxoSmithKline |
2001-04 | PHASE3 |
| NCT00005029 | TERMINATED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2000-02 | PHASE2 |
| NCT00002948 | TERMINATED | Unspecified Adult Solid Tumor, Protocol Specific |
Yale University |
1996-10 | PHASE1 |
| NCT00187083 | COMPLETED | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
1997-02 | PHASE3 |
| NCT00025311 | COMPLETED | Brain and Central Nervous System Tumors |
NYU Langone Health |
2001-05 | PHASE1 |
| NCT00014443 | TERMINATED | Brain and Central Nervous System Tumors |
Rush University Medical Center |
2000-08 | PHASE2 |
| NCT00002643 | COMPLETED | Neutropenia; Sarcoma |
National Cancer Institute (NCI) |
1995-04 | PHASE2 |
| NCT00003745 | COMPLETED | Sarcoma |
National Cancer Institute (NCI) |
1999-05 | PHASE2 |
| NCT00005021 | COMPLETED | Lymphoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Fox Chase Cancer Center |
1996-07 | PHASE1 |
| NCT00005051 | COMPLETED | Ovarian Cancer |
NYU Langone Health |
1999-08 | PHASE2 |
| NCT00003194 | TERMINATED | Unspecified Childhood Solid Tumor, Protocol Specific |
Seattle Children's Hospital |
1997-07 | PHASE1 |
| NCT00003735 | COMPLETED | Leukemia |
Children's Oncology Group |
1998-12 | PHASE2 |
| NCT00041015 | COMPLETED | Lung Cancer |
Case Comprehensive Cancer Center |
2001-09 | PHASE3 |
| NCT00652691 | COMPLETED | Ovarian Cancer; Peritoneal Cavity Cancer |
Mayo Clinic |
1998-08 | PHASE1 |
| NCT00005593 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Case Comprehensive Cancer Center |
1998-09 | PHASE1 |
| NCT00002950 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Yale University |
1996-09-26 | PHASE1; PHASE2 |
| NCT00004221 | TERMINATED | Malignant Ovarian Mixed Epithelial Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Primary Peritoneal Carcinoma; Stage III Ovarian Cancer; Undifferentiated Ovarian Carcinoma |
Gynecologic Oncology Group |
1999-11 | PHASE2 |
| NCT00003675 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Alliance for Clinical Trials in Oncology |
1999-03 | PHASE2 |
| NCT00003331 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Precancerous Condition; Unspecified Adult Solid Tumor, Protocol Specific |
NYU Langone Health |
1998-01 | PHASE1 |
| NCT00003917 | COMPLETED | Lung Cancer |
Case Comprehensive Cancer Center |
1999-03 | PHASE3 |
| NCT00006374 | WITHDRAWN | Lung Cancer |
Case Comprehensive Cancer Center |
1999-10 | PHASE2 |
| NCT00002734 | COMPLETED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
National Cancer Institute (NCI) |
1996-03 | PHASE1 |
| NCT00002814 | COMPLETED | Brain and Central Nervous System Tumors |
Dartmouth-Hitchcock Medical Center |
1996-08 | PHASE2 |
| NCT00006032 | TERMINATED | Breast Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2000-03 | PHASE2 |
| NCT00186849 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
1997-10 | PHASE2 |
| NCT00002705 | COMPLETED | Leukemia |
National Cancer Institute (NCI) |
1996-04 | PHASE1 |
| NCT00100477 | COMPLETED | Non-Hodgkin's Lymphoma; Leukemia |
US Department of Veterans Affairs |
1998-08 | PHASE2 |
| NCT00003297 | COMPLETED | Ovarian Cancer |
Georgetown University |
1997-12 | PHASE1; PHASE2 |
| NCT00002587 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
1994-09 | PHASE1 |
| NCT00003943 | COMPLETED | Carcinoma of Unknown Primary; Lung Cancer |
Fox Chase Cancer Center |
1998-09 | PHASE2 |
| NCT00003372 | COMPLETED | Brain and Central Nervous System Tumors |
NCIC Clinical Trials Group |
1997-12-08 | PHASE2 |
| NCT00004060 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Daiichi Sankyo |
1999-07 | PHASE2 |
| NCT00002588 | COMPLETED | Leukemia |
Case Comprehensive Cancer Center |
1994-08 | PHASE1 |
| NCT00003198 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
1997-11 | PHASE1 |
| NCT00002625 | COMPLETED | Esophageal Cancer; Lung Cancer; Lymphoma |
National Cancer Institute (NCI) |
1995-03 | PHASE1 |
| NCT00003340 | COMPLETED | Leukemia |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
1997-11 | PHASE2 |
| NCT00003944 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Fox Chase Cancer Center |
1998-08 | PHASE2 |
| NCT00003827 | UNKNOWN | Leukemia; Myelodysplastic Syndromes |
ALZA |
1999-01 | PHASE2 |
| NCT00001335 | COMPLETED | Ewing's Sarcoma; Neuroblastoma; Rhabdomyosarcoma |
National Cancer Institute (NCI) |
1993-04 | PHASE2 |
| NCT00003732 | COMPLETED | Ovarian Cancer |
Rigshospitalet, Denmark |
1998-09 | PHASE2 |
| NCT00488709 | COMPLETED | Acute Myeloid Leukemia |
PETHEMA Foundation |
2003-05 | PHASE4 |
| NCT00189566 | COMPLETED | Ovarian Cancer; Fallopian Tube Cancer; Malignant Tumor of Peritoneum |
ARCAGY/ GINECO GROUP |
2004-04 | PHASE2 |
| NCT00002395 | COMPLETED | HIV Infections; Leukoencephalopathy, Progressive Multifocal |
SmithKline Beecham |
PHASE2 | |
| NCT00179712 | COMPLETED | Ovarian Cancer |
Celgene Corporation |
2005-04 | PHASE1; PHASE2 |
| NCT00295243 | COMPLETED | Advanced Solid Malignancies |
Mayo Clinic |
2004-09 | PHASE1 |
| NCT00231855 | COMPLETED | Ovarian Neoplasms; Uterine Neoplasms |
Montefiore Medical Center |
2004-11 | PHASE2 |
| NCT00003415 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
University of Arizona |
1998-09 | PHASE1; PHASE2 |
| NCT00006199 | UNKNOWN | Cancer |
National Center for Research Resources (NCRR) |
PHASE1 | |
| NCT00502762 | UNKNOWN | Lung Cancer; Refractory to Chemotherapy |
Gachon University Gil Medical Center |
2004-09 | PHASE2 |
| NCT00003733 | UNKNOWN | Ovarian Cancer |
SmithKline Beecham |
1997-12 | PHASE2 |
| NCT00322920 | TERMINATED | Cervix Cancer |
University of Alabama at Birmingham |
2005-07 | PHASE1 |
| NCT00888810 | TERMINATED | Cancer; Ovarian; Relapse; Chemotherapy |
Centre Francois Baclesse |
2008-03 | PHASE2 |
| NCT00314678 | COMPLETED | Epithelial Ovarian Cancer; Primary Peritoneal Cancer |
John P. Fruehauf |
2005-09 | PHASE2 |
| NCT00055614 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Beth Israel Deaconess Medical Center |
2002-05 | PHASE1 |
| NCT00102375 | COMPLETED | Ovarian Cancer |
AGO Study Group |
1999-12 | PHASE3 |
| NCT00003064 | UNKNOWN | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Herbert Irving Comprehensive Cancer Center |
1997-01 | PHASE1; PHASE2 |
| NCT00046800 | COMPLETED | Ovarian Neoplasms |
Astellas Pharma Inc |
2002-09 | PHASE2 |
| NCT00014690 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
AstraZeneca |
2001-03 | PHASE2 |
| NCT00412503 | COMPLETED | Refractory Tumors; Malignant Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
PHASE1 | |
| NCT00187031 | COMPLETED | Wilms Tumor |
St. Jude Children's Research Hospital |
2002-11 | PHASE2 |
| NCT00194935 | TERMINATED | Ovarian Cancer |
Weill Medical College of Cornell University |
2003-02 | PHASE2 |
| NCT00312988 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2000-01 | PHASE3 |
| NCT00276276 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2000-11 | PHASE3 |
| NCT00001333 | COMPLETED | Leukemia; Lymphoma; Meningeal Neoplasms |
National Cancer Institute (NCI) |
1993-02 | PHASE1 |
| NCT00003065 | COMPLETED | Cervical Cancer |
Herbert Irving Comprehensive Cancer Center |
1997-01 | PHASE2 |
| NCT00003619 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; Thrombocytopenia |
Drexel University College of Medicine |
1998-02 | PHASE1; PHASE2 |
| NCT00004979 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Jonsson Comprehensive Cancer Center |
PHASE1; PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-02-12)
Check the
Topotecan (SKF 104864A)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Topotecan (SKF 104864A) Solubility in DMSO
- Topotecan (SKF 104864A) Stock Solution
- Topotecan (SKF 104864A) Storage
- Topotecan (SKF 104864A) Stability
- Topotecan (SKF 104864A) Molecular Weight
- Topotecan (SKF 104864A) SMILES
- Topotecan (SKF 104864A) CAS Number
- Topotecan (SKF 104864A) Chemical Structure (2D and 3D)
- Topotecan (SKF 104864A) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.