CAS No. 115103-54-3
Batch:
Purity:99.56
Chemical Structure
Check the
Tiagabine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 115103-54-3 | |
| Molecular Formula |
C20H25NO2S2 |
|
| Molecular Weight (MW) | 375.55 | |
| SMILES | CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C | |
| InChIKey | PBJUNZJWGZTSKL-MRXNPFEDSA-N |
Biological Activity
Tiagabine is a selective inhibitor of the GABA transporter 1 (GAT-1) and functions as an anticonvulsant agent. By blocking GAT-1-mediated GABA reuptake into presynaptic neurons and glial cells, it increases extracellular GABA concentrations within synaptic clefts in the central nervous system. This enhancement of inhibitory GABAergic neurotransmission effectively suppresses neuronal hyperexcitability and elevates seizure thresholds, thereby attenuating epileptiform activity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 75 mg/mL |
| Ethanol | 75 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.