Home Neuronal Signaling Dopamine Receptor antagonist Thiethylperazine

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Thiethylperazine Dopamine Receptor antagonist

Cat.No.E6634

Thiethylperazine is a phenothiazine derivative that acts as an oral dopamine D2-receptor and histamine H1-receptor antagonist. This compound functions as an ABCC1 activator and has been shown to decrease amyloid-β (Aβ) accumulation in mice. It exhibits anti-emetic, antipsychotic, and antimicrobial properties.
Thiethylperazine Dopamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 399.62

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Chemical Information, Storage & Stability

Molecular Weight 399.62 Formula C22H29N3S2 Storage (From the date of receipt)
CAS No. 1420-55-9 Download SDF Storage of Stock Solutions

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Mechanism of Action

In vivo
Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice.
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