Home Immunology & Inflammation TLR antagonist - Other antagonist TH1020

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TH1020 TLR antagonist

TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist, with an IC50 value of 0.85 μM. TH1020 inhibits downstream signaling pathways activated by the TLR5/Flagellin complex. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8.

TH1020 TLR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 453.54

Purity & Quality Control

Related Products

Mechanism of Action

References
  • https://pubmed.ncbi.nlm.nih.gov/26634412/
  • https://pubmed.ncbi.nlm.nih.gov/31221216

Chemical Information

Molecular Weight 453.54 Formula

C23H15N7S2
CAS No. 1841460-82-9 SDF Download SDF
Smiles C12=NC=NC(SC3=NN=C(N3CC4=CC=CC=C4)C5=CC=NC=C5)=C1SC6=NC=CC=C62

Storage and Stability

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