Serotonin Hydrochloride (5-HT HCl) Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 490

Clinical Trials

Numerous clinical trials investigate serotonin signaling and serotonergic modulation across conditions such as major depressive disorder, insomnia, anorexia nervosa, and coronary artery disease. Spanning Early Phase 1 through Phase 4 alongside non-applicable phases, these evaluations encompass active, completed, terminated, and not yet recruiting studies. These research initiatives are sponsored by diverse entities, including academic institutions, specialized psychiatric centers, national health organizations, and biotechnology companies.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07716982	NOT_YET_RECRUITING	Depression Disorder	Hôpital le Vinatier	2026-09
NCT07189299	NOT_YET_RECRUITING	PMS; PMDD	Friederike Holze	2025-10-01
NCT06704594	RECRUITING	Premenstrual Dysphoric Disorder (PMDD)	Johns Hopkins University	2025-05-14	PHASE4
NCT07390981	NOT_YET_RECRUITING	Major Depressive Disorder	First People's Hospital of Hangzhou	2026-03-01
NCT07651293	NOT_YET_RECRUITING	Depression - Major Depressive Disorder	Imperial College Healthcare NHS Trust	2026-07-01
NCT07565493	RECRUITING	Psychedelic Effects in Healthy Volunteers	Johns Hopkins University	2026-08-12	EARLY_PHASE1
NCT06592833	RECRUITING	Major Depressive Disorder	Icahn School of Medicine at Mount Sinai	2025-02-25	PHASE2
NCT07013331	RECRUITING	Epilepsy; Dravet Syndrome; Drug Resistant Epilepsy; Healthy Controls	Hospices Civils de Lyon	2026-05-04
NCT04336228	ACTIVE_NOT_RECRUITING	Obsessive-Compulsive Disorder/High Compulsive Individuals; Healthy Individuals	Rigshospitalet, Denmark	2020-04-01	PHASE4
NCT07359482	RECRUITING	Post-COVID; POST-Covid 19; Post-COVID Conditions	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2026-06-04	PHASE3
NCT05953038	ACTIVE_NOT_RECRUITING	Basic Science	Rigshospitalet, Denmark	2023-11-08	EARLY_PHASE1
NCT07318181	RECRUITING	Post Traumatic Stress Disorder; Post Traumatic Stress Disorder PTSD; Post-Traumatic Stress Disorder, PTSD	University of Luxembourg	2026-01-01
NCT07703722	RECRUITING	Major Depressive Disorder; Post-Traumatic Stress Disorder (PTSD)	Khyber Medical University Peshawar	2026-04-01	PHASE3
NCT06225011	RECRUITING	Colorectal Adenocarcinoma	Jonsson Comprehensive Cancer Center	2025-03-20	PHASE1
NCT04123314	RECRUITING	Depressive Symptoms; Depression; Alzheimer Disease; Mild Cognitive Impairment	Johns Hopkins University	2021-03-24	EARLY_PHASE1
NCT05357612	RECRUITING	Neurodegenerative Diseases; Parkinson Disease; Parkinson Disease Psychosis	Vanderbilt University Medical Center	2023-01-23	PHASE4
NCT06512220	RECRUITING	Treatment Resistant Depression	Centre for Addiction and Mental Health	2025-04-21	PHASE2
NCT07602387	RECRUITING	Patients With Taxane-induced Chronic Neuropathic Pain	Hospital Ambroise Paré Paris	2024-03-12
NCT07452341	NOT_YET_RECRUITING	Depression	Cairo University	2026-08-01
NCT06545474	NOT_YET_RECRUITING	Major Depressive Disorder	University Hospital Tuebingen	2024-09-15
NCT06559306	RECRUITING	Depressive Disorder, Major	Janssen Research & Development, LLC	2024-07-25	PHASE3
NCT07067970	NOT_YET_RECRUITING	Premature Ejaculation	Medipol University	2025-10-01
NCT07708428	NOT_YET_RECRUITING	Healthy Volunteers (HV)	LinGang Laboratory	2026-07-24	PHASE1
NCT03228732	RECRUITING	Type 1 Diabetes Mellitus	University of Maryland, Baltimore	2017-12-19	EARLY_PHASE1
NCT07153406	NOT_YET_RECRUITING	Depressive Disorder	Fundación Pública Andaluza para la gestión de la Investigación en Sevilla	2025-09-15	PHASE3
NCT06008704	RECRUITING	Parkinson Disease	University Hospital, Toulouse	2024-01-01
NCT05469165	RECRUITING	Ischemic Mitral Regurgitation	Laval University	2023-06-20	PHASE2
NCT06796361	RECRUITING	Healthy	University Hospital, Basel, Switzerland	2025-04-21	PHASE1
NCT07329621	TERMINATED	Healthy Volunteers	Otsuka Pharmaceutical Development & Commercialization, Inc.	2026-01-15	PHASE1
NCT04520178	RECRUITING	Spinal Cord Injuries	University of Alberta	2020-07-01	PHASE2; PHASE3
NCT07017478	COMPLETED	LSD; Major Depressive Disorder; Depression	University of Chicago	2025-06-09	EARLY_PHASE1
NCT07022366	RECRUITING	Healthy	University of Oxford	2025-02-10
NCT07404813	ENROLLING_BY_INVITATION	Patient Engagement; Intensive Care (ICU); Family Members' Voices	Zeliha CENGİZ	2025-02-20
NCT07057011	NOT_YET_RECRUITING	Premature Ejaculation	South Valley University	2025-07-01
NCT06955845	COMPLETED	PTSD; PTSD - Post Traumatic Stress Disorder	Asad Ullah Jan	2025-05-06
NCT05705830	UNKNOWN	Anxiety Disorder; Insomnia	Second Affiliated Hospital, Zhejiang University, School of Medicine	2022-11-01
NCT06081179	COMPLETED	Healthy	University of Zurich	2023-10-24	PHASE1
NCT06363968	RECRUITING	PTSD; Posttraumatic Stress Disorder	VA Puget Sound Health Care System	2024-02-12
NCT00285935	COMPLETED	Major Depressive Disorder	University of California, San Francisco	2010-12-16
NCT05155280	TERMINATED	Anorexia Nervosa	Centre Hospitalier Universitaire de Saint Etienne	2021-12-10
NCT06856447	RECRUITING	Colorectal Cancer	toqa saad mohammed mohammed	2024-06-01	PHASE1
NCT06476509	COMPLETED	Major Depressive Disorder	Vigonvita Life Sciences	2024-05-30	PHASE1
NCT06211140	UNKNOWN	Major Depressive Disorder	Xuanwu Hospital, Beijing	2024-01-31
NCT03994965	WITHDRAWN	Schizophrenia; Psychosis	Bjorn H. Ebdrup	2024-12-01	PHASE2
NCT04977271	WITHDRAWN	Depressive Disorder; Head and Neck Cancer	University of Alabama at Birmingham	2024-01-05	PHASE4
NCT05651126	COMPLETED	Autism Spectrum Disorder	King's College London	2022-12-12
NCT04597190	COMPLETED	PTSD	University of Washington	2020-06-01	PHASE4
NCT05957094	UNKNOWN	Depression; Serotonin Deficiency	University of British Columbia	2023-08
NCT06457581	UNKNOWN	Pain; Fibromyalgia	Superior University	2023-11-01
NCT03222570	COMPLETED	Depressive Disorder	University of Minnesota	2018-02-26	PHASE2
NCT06381479	Recruiting	Stress\|Sleep Disorder	National Taiwan Sport University\|Bened Biomedical Co. Ltd.	2024-04-19	Not Applicable
NCT06361368	Not yet recruiting	Insomnia	National Yang Ming University\|Bened Biomedical Co. Ltd.	2024-04	Not Applicable
NCT06185361	UNKNOWN	Nocturnal Enuresis; Enuresis; Enuresis, Nocturnal	Fayoum University Hospital	2022-12-01
NCT05175430	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2022-10-24	PHASE1
NCT04653337	UNKNOWN	Suicidal Ideation; Depression	Xijing Hospital	2020-09-28	PHASE2
NCT05181527	COMPLETED	Major Depressive Disorder	All India Institute of Medical Sciences, Bhubaneswar	2022-02-10	PHASE4
NCT04216329	ACTIVE_NOT_RECRUITING	Gliosarcoma; Newly Diagnosed; Glioblastoma	National Cancer Institute (NCI)	2020-07-07	PHASE1
NCT05470465	COMPLETED	Hypercapnia; Ventilatory Depression	Food and Drug Administration (FDA)	2022-09-01	PHASE1
NCT04218123	COMPLETED	Meniere Disease	Medical University of South Carolina	2020-02-05	PHASE2; PHASE3
NCT01851369	COMPLETED	Lymphomas; Solid Tumors; NSCLC; Metastatic Colon Carcinoma; Granulosa Cell Ovarian Cancer	National Cancer Institute (NCI)	2013-07-12	PHASE1; PHASE2
NCT05786677	UNKNOWN	Fibromyalgia; Depression	Cairo University	2023-04-01
NCT06451406	COMPLETED	Selective Serotonin Reuptake Inhibitor; Hyaluronic Acid; Glans Penis; Lifelong Premature	New Valley University	2022-10-01
NCT05588102	COMPLETED	Geriatric Depression; Cognitive Impairment	Capital Medical University	2021-05-18
NCT03993535	COMPLETED	Obsessive-Compulsive Disorder	University of Sao Paulo	2018-10-10	PHASE4
NCT05481294	UNKNOWN	HIV	Muh. Yusuf Tahir	2021-12-16
NCT05357547	COMPLETED	Anhedonia	University of Oxford	2022-05-13	PHASE2
NCT04849013	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2021-08-11	PHASE1
NCT05594667	WITHDRAWN	Depression; Major Depressive Disorder; Mild Depression; Moderate Depression; Depressive Disorder	Cybin Therapeutics Inc.	2023-01-01	PHASE2
NCT03790358	COMPLETED	Healthy	University of Chicago	2018-05-01	PHASE1
NCT05647148	UNKNOWN	Sleep Disturbance; Nursing Care	Ataturk University	2022-05-09
NCT04209166	UNKNOWN	Major Depressive Disorder	Shanghai Mental Health Center	2019-08-12
NCT04676139	UNKNOWN	Nocturnal Enuresis	Mansoura University	2020-07-01	PHASE3
NCT04528628	UNKNOWN	Major Depressive Disorder	Shanghai Mental Health Center	2020-10
NCT03910387	COMPLETED	Locally Advanced Unresectable Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Recurrent Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8	Emory University	2019-04-17	PHASE2
NCT04873648	UNKNOWN	Eating Disorders; Intermittent Fasting; Obesity	University of Jordan	2021-06-20
NCT04101227	COMPLETED	Alcohol Use Disorder	Adial Pharmaceuticals	2020-02-01	PHASE3
NCT03970239	UNKNOWN	Parkinson Disease; Impulse Control Disorders	Hospices Civils de Lyon	2019-05-13
NCT02767999	COMPLETED	Stroke	University Hospital, Toulouse	2017-02-27	PHASE4
NCT04338321	COMPLETED	Depressive Disorder, Major	Janssen-Cilag International NV	2020-08-21	PHASE3
NCT04904952	UNKNOWN	OCD	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2020-03-13
NCT04246905	UNKNOWN	Depressive Disorder	Central South University	2020-07-15	PHASE2
NCT04880460	COMPLETED	MDD	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2021-03-18	PHASE2
NCT02359513	COMPLETED	Bulimia Nervosa	Centre Hospitalier Universitaire de Saint Etienne	2015-11-09	PHASE4
NCT04917458	UNKNOWN	Diabetes Mellitus, Type 2; Depressive Symptoms	Indonesia University	2021-01-18	PHASE2
NCT02466685	COMPLETED	Bipolar Disorder	Herbert Meltzer	2015-09	PHASE2
NCT04690270	UNKNOWN	Overweight	Cambridge University Hospitals NHS Foundation Trust	2021-01-04	EARLY_PHASE1
NCT03934710	COMPLETED	Healthy	University of Chicago	2019-04-20	PHASE1
NCT03549182	UNKNOWN	Healthy	University of Electronic Science and Technology of China	2017-03-01
NCT04478526	COMPLETED	Generalized Anxiety Disorder	Dr. Nazanin Alavi	2020-04-29
NCT03347331	COMPLETED	Neurological Pathology; Healthy Subjects	Hospices Civils de Lyon	2018-04-23	EARLY_PHASE1
NCT05659472	COMPLETED	Depression	Health Technology Institute of Cendekia Utama Kudus	2020-12-12
NCT04054193	COMPLETED	Chemotherapy-induced Nausea and Vomiting	Merck Sharp & Dohme LLC	2019-09-09	PHASE4
NCT04221256	WITHDRAWN	Stroke, Ischemic	Burke Medical Research Institute	2020-03-11	PHASE1; PHASE2
NCT04430361	UNKNOWN	Tumor; Chemotherapy-induced Nausea and Vomiting	Henan Cancer Hospital	2018-09-07	PHASE2
NCT03527316	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2019-10-18	EARLY_PHASE1
NCT02715232	UNKNOWN	Gender Dysphoria	Medical University of Vienna	2017-02-06	PHASE4
NCT01568307	COMPLETED	Major Depressive Disorder	Baker Heart and Diabetes Institute	2012-05	PHASE4
NCT03912974	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2019-07-04	PHASE1
NCT02865642	UNKNOWN	Stroke	Insel Gruppe AG, University Hospital Bern	2016-08	PHASE2
NCT04482296	COMPLETED	MDD	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2019-09-15
NCT03601871	UNKNOWN	Chemotherapy-induced Nausea and Vomiting	Yunpeng Liu	2018-07-12
NCT07644065	COMPLETED	Impacted Third Molar; Postoperative Pain; Neuroinflammation; Anxiety	Plovdiv Medical University	2019-09-30
NCT04192162	UNKNOWN	Osteoarthritis of Multiple Joints	Specialized Rehabilitation Hospital Banja Koviljaca	2019-12-18
NCT01975480	COMPLETED	Generalized Anxiety Disorder	START Clinic for Mood and Anxiety Disorders	2013-01	PHASE4
NCT02717052	UNKNOWN	Depression; Ketamine	Medical University of Vienna	2016-05	PHASE2
NCT03973567	UNKNOWN	Therapeutic Mechanism of Antidepressants for Refractory FD	Second Affiliated Hospital, Zhejiang University, School of Medicine	2017-01-01
NCT03249311	UNKNOWN	None (i.e. Healthy Volunteers)	University of Ottawa	2018-03-02	PHASE4
NCT03943251	COMPLETED	Healthy	Sunshine Lake Pharma Co., Ltd.	2019-07-04	PHASE1
NCT03679702	UNKNOWN	Sexual Dysfunction	Michael Krychman, MD	2018-12-15
NCT02473250	COMPLETED	Bipolar Disorder	New York State Psychiatric Institute	2015-01	PHASE4
NCT02137369	COMPLETED	Depression	Emory University	2014-09	PHASE4
NCT02753738	UNKNOWN	Ssri; Neuronal Plasticity	Medical University of Vienna	2016-08	PHASE4
NCT03576053	COMPLETED	Itch; Thermal Stimulation; Histamine; Cowhage; Serotonine	Aalborg University	2018-07-01
NCT03321136	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2017-11-28	EARLY_PHASE1
NCT03833999	COMPLETED	Motility Disorder of Intestine; Ondansetron; Small Bowel Water	University of Nottingham	2018-10-16	PHASE4
NCT03041870	COMPLETED	Healthy Volunteers	Hospices Civils de Lyon	2017-11-14
NCT03577457	UNKNOWN	Healthy	University of Electronic Science and Technology of China	2018-02-01
NCT03426176	UNKNOWN	Healthy	University of Electronic Science and Technology of China	2018-02-01
NCT03321526	COMPLETED	Depressive Disorder, Major	Janssen Research & Development, LLC	2017-12-12	PHASE2
NCT02851914	COMPLETED	Depression; Amyotrophic Lateral Sclerosis	St. Louis University	2015-07-21	EARLY_PHASE1
NCT03754647	UNKNOWN	OCD	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2017-12-14
NCT03754712	UNKNOWN	MDD	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2018-03-10
NCT02669056	COMPLETED	Very Premature Infants	Assistance Publique Hopitaux De Marseille	2015-12-17
NCT00182520	COMPLETED	Obsessive Compulsive Disorder	McMaster University	2002-01	PHASE4
NCT00994786	COMPLETED	Obsessive-Compulsive Disorder	McMaster University	2009-01	PHASE4
NCT01674686	UNKNOWN	Variant Angina	Samsung Medical Center	2012-08-01	PHASE4
NCT02153567	COMPLETED	Dyspepsia; Anxiety; Depression	Chinese University of Hong Kong	2013-12-06	PHASE3
NCT00182455	TERMINATED	Social Phobia	McMaster University	2004-03-01	PHASE4
NCT06212284	COMPLETED	Healthy	University of Sussex	2018-02-18
NCT01208324	COMPLETED	Menopause	University of Colorado, Denver	2010-03-04
NCT03019822	COMPLETED	Healthy	University Hospital, Basel, Switzerland	2017-02-01	EARLY_PHASE1
NCT01811147	COMPLETED	Bipolar Disorder; Major Depression	The Cleveland Clinic	2011-11	PHASE4
NCT03364075	TERMINATED	Low Back Pain	Mark Ware	2017-09-01	PHASE2
NCT03233906	UNKNOWN	Obesity; Eating Behavior; Mood; Glucose; Dietary Modification	California State Polytechnic University, Pomona	2017-05-20
NCT02895932	COMPLETED	Parkinson's Disease	University of Michigan	2015-01
NCT02858635	UNKNOWN	Suicidal Behaviour	University Hospital, Montpellier	2001-09
NCT02492347	COMPLETED	Qt Interval, Variation in; Adverse Effect of Selective Serotonin Reuptake Inhibitors	University of Southampton	2016-02-18
NCT02825342	TERMINATED	Chest Pain Rule Out Myocardial Infarction	Evangelismos Hospital	2014-03	PHASE4
NCT02824081	UNKNOWN	Major Depressive Episode; Suicidal Behavior	University Hospital, Montpellier	2015-11
NCT03638908	COMPLETED	Pulmonary Arterial Hypertension	University of Texas Southwestern Medical Center	2013-11	PHASE2
NCT01695291	COMPLETED	Obsessive Compulsive Disorder	New York State Psychiatric Institute	2012-05	PHASE2
NCT01450826	COMPLETED	Nausea; Vomiting; Glioma	Katy Peters	2014-06-24	PHASE2
NCT02386475	COMPLETED	Stroke	Hospital de Granollers	2015-01	PHASE4
NCT02519842	TERMINATED	Chemotherapy-induced Nausea and Vomiting	Merck Sharp & Dohme LLC	2015-09-14	PHASE3
NCT02916628	TERMINATED	Smoking	Inha University Hospital	2013-07
NCT02228005	COMPLETED	Depression	University Health Network, Toronto	2014-07	PHASE4
NCT01535573	COMPLETED	Cocaine Dependence	Joy Schmitz	2010-12	PHASE2
NCT02285699	COMPLETED	Obsessive-Compulsive Disorder	McMaster University	2014-11-01
NCT02333487	COMPLETED	Schizophrenia	H. Lundbeck A/S	2014-12-30	PHASE1
NCT02607436	COMPLETED	Coronary Artery Disease	Seoul National University Bundang Hospital	2015-07	PHASE4
NCT02463110	TERMINATED	Depression; Coronary Artery Disease	Assistance Publique - Hôpitaux de Paris	2015-07	PHASE4
NCT02014363	COMPLETED	Major Depressive Disorder	e-Therapeutics PLC	2013-10	PHASE2
NCT01275248	TERMINATED	Obsessive-compulsive Disorder	Transcept Pharmaceuticals	2011-01	PHASE2
NCT00523718	COMPLETED	Obsessive-compulsive Disorder; Ocd	Yale University	2006-09	PHASE2
NCT02038608	COMPLETED	Parkinson's Disease	Hospices Civils de Lyon	2014-12
NCT01674361	COMPLETED	Obsessive-Compulsive Disorder	Hoffmann-La Roche	2012-12-31	PHASE2
NCT03209427	COMPLETED	Pruritus	Assiut University	2014-04-02	PHASE4
NCT01617070	COMPLETED	Phenylketonuria (PKU)	University of Southern California	2012-05	PHASE4
NCT01361815	COMPLETED	Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified	Brainsway	2011-07
NCT02092974	COMPLETED	Healthy Young and Older Adults	Charite University, Berlin, Germany	2014-04	PHASE1
NCT01813019	TERMINATED	Patient Diagnosed With OCD and Resistant to SSRI Treatment; Failed SSRI Over 12 Weeks at Appropriate Doses	Novartis Pharmaceuticals	2013-11	PHASE2
NCT02963545	COMPLETED	Cerebral Infarction	Versailles Hospital	2012-10
NCT01160263	COMPLETED	Amyotrophic Lateral Sclerosis	Assistance Publique - Hôpitaux de Paris	2012-10	PHASE3
NCT01555970	COMPLETED	Obsessive-Compulsive Disorder	University of Sao Paulo	2012-03	PHASE2
NCT02262156	COMPLETED	Depression; Epilepsy, Temporal Lobe	El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez	2014-08
NCT02230371	COMPLETED	Myofascial Pain; Temporomandibular Disorders	Karolinska Institutet	2007-03	PHASE4
NCT01148979	COMPLETED	Major Depressive Disorder	Mclean Hospital	2010-09	PHASE4
NCT02175602	COMPLETED	Hepatitis C Infection	Bristol-Myers Squibb	2014-06	PHASE1
NCT02314195	COMPLETED	Obsessive-Compulsive Disorder; Anxiety; Depression	Islamic Azad University, Marvdasht	2014-04
NCT01178671	COMPLETED	Posttraumatic Stress Disorder	Research Foundation for Mental Hygiene, Inc.	2010-07	PHASE4
NCT01175616	WITHDRAWN	Major Depressive Disorder	University of Utah	2012-09	PHASE4
NCT00633399	COMPLETED	Major Depressive Disorder	Massachusetts General Hospital	2008-07	PHASE2
NCT02051530	COMPLETED	Mood; Social Behavior	University of Groningen	2012-04	EARLY_PHASE1
NCT01370499	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2011-08	PHASE3
NCT02051569	COMPLETED	Social Behaviour	University of Groningen	2012-08	EARLY_PHASE1
NCT01065220	COMPLETED	Transsexualism	Medical University of Vienna	2010-02	PHASE4
NCT02015546	COMPLETED	Major Depressive Disorder (MDD)	Duke University	2012-12	PHASE3
NCT01364649	COMPLETED	Treatment Outcome	Takeda	2011-06	PHASE3
NCT01778686	COMPLETED	Healthy	Gitte Moos Knudsen	2013-01
NCT01173601	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2010-11	PHASE3
NCT01148264	TERMINATED	Emesis	Karin Jordan	2010-07	PHASE2
NCT01456052	COMPLETED	Ulcerative Colitis	Lexicon Pharmaceuticals	2012-01-30	PHASE2
NCT01187407	COMPLETED	Major Depressive Disorder (MDD)	Eli Lilly and Company	2011-03	PHASE3
NCT00517764	COMPLETED	Depression	Centre for Addiction and Mental Health	2006-12
NCT01185340	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2011-03	PHASE3
NCT00732901	COMPLETED	Cocaine Dependence	Virginia Commonwealth University	2008-06	PHASE2; PHASE3
NCT01318434	COMPLETED	Major Depressive Disorder	Euthymics BioScience, Inc.	2011-02	PHASE2; PHASE3
NCT00955474	TERMINATED	Major Depressive Disorder With Psychotic Features	Massachusetts General Hospital	2008-09	PHASE4
NCT01155661	COMPLETED	Depressive Disorder, Major	Eli Lilly and Company	2010-10	PHASE3
NCT02473783	COMPLETED	Major Depressive Disorder	Tri-Service General Hospital (TSGH)	2011-10	PHASE2
NCT01461083	COMPLETED	Parkinson Disease	Institute for Neurodegenerative Disorders	2011-09	PHASE1
NCT01548937	COMPLETED	Melancholia	Chang Gung Memorial Hospital	2010-05	PHASE2
NCT02833090	COMPLETED	Aortic Stenosis	University Hospital, Toulouse	2010-02
NCT04352686	COMPLETED	Gastroesophageal Reflux	Universitaire Ziekenhuizen KU Leuven	2012-02
NCT01297738	COMPLETED	Obesity; Diabetes Mellitus Type 2	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2011-02
NCT01531972	COMPLETED	Healthy	Sumitomo Pharma America, Inc.	2012-02	PHASE1
NCT01313403	WITHDRAWN	Major Depression; Unipolar Depression; Depression; Anxiety Disorder	National Institute of Mental Health (NIMH)	2011-02-10
NCT02132286	COMPLETED	Major Depressive Disorder	University of Calgary	2008-12	PHASE4
NCT01097980	COMPLETED	Sexual Dysfunction	Beitou Armed Forces Hospital, Taipei, Taiwan	2010-04
NCT01264861	TERMINATED	Parkinson Disease	Newron Pharmaceuticals SPA	2011-03	PHASE2
NCT00641108	COMPLETED	Depression	University of Pennsylvania	2008-01	PHASE2; PHASE3
NCT01517438	COMPLETED	Agitation	Seoul National University Hospital	2011-03
NCT01101152	UNKNOWN	Healthy	University of Ottawa	2010-04	PHASE1
NCT04355455	COMPLETED	Gastroesophageal Reflux	Universitaire Ziekenhuizen KU Leuven	2011-07
NCT02172859	COMPLETED	Healthy	dsm-firmenich Switzerland AG	2010-11	PHASE2
NCT01045083	COMPLETED	Healthy Volunteer	Hoffmann-La Roche	2010-01	PHASE1
NCT01189825	COMPLETED	Sexual Dysfunction	University of Texas at Austin	2009-06
NCT00539513	TERMINATED	Obsessive-Compulsive Disorder	Yale University	2006-06	PHASE2
NCT01358006	COMPLETED	Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2010-11	PHASE1
NCT01263223	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2010-12	PHASE1
NCT01101685	COMPLETED	Dysphoria	University of Oxford	2010-02	PHASE4
NCT01638689	COMPLETED	Healthy	Karolinska Institutet	2010-09	PHASE1
NCT00254020	COMPLETED	Depression	Sunnybrook Health Sciences Centre	2005-06	PHASE4
NCT01040208	TERMINATED	Sexual Dysfunctions, Psychological; Depression	Sprout Pharmaceuticals, Inc	2010-01	PHASE3
NCT00657163	COMPLETED	Ischemic Stroke; Motor Impairment	University Hospital, Toulouse	2005-03	PHASE2
NCT01018108	COMPLETED	Breast Cancer	Abramson Cancer Center at Penn Medicine	2009-03	PHASE1
NCT00894543	COMPLETED	Hot Flashes; Menopause; Vasomotor Symptoms	Fred Hutchinson Cancer Center	2009-07
NCT00411398	COMPLETED	General Anxiety Disorder, Social Anxiety Disorder	State University of New York - Upstate Medical University	2006-12	PHASE3
NCT00086307	COMPLETED	Major Depression	National Institute of Mental Health (NIMH)	2004-06	PHASE2
NCT00840034	COMPLETED	Depressive Disorder, Major	Eli Lilly and Company	2009-02	PHASE2
NCT00838305	COMPLETED	MDMA Mechanism of Action	California Pacific Medical Center Research Institute	2009-02
NCT00145132	COMPLETED	Depression	Ludwig-Maximilians - University of Munich	2005-06	PHASE4
NCT00704860	COMPLETED	Major Depression	University of Ottawa	2005-02	PHASE4
NCT00074815	COMPLETED	Obsessive-Compulsive Disorder	Duke University	2003-09	PHASE3
NCT01153802	COMPLETED	Depressive Disorder	GlaxoSmithKline	2009-04-03	PHASE1
NCT00129467	COMPLETED	Depression; Palliative Care; Cancer; Mental Disorder	US Department of Veterans Affairs	2005-02
NCT00427674	TERMINATED	Parkinson Disease	Institute for Neurodegenerative Disorders	2007-01	PHASE1
NCT00902421	COMPLETED	Overactive Bladder	Samsung Medical Center	2007-01	PHASE4
NCT00211809	TERMINATED	Body Dysmorphic Disorder	Icahn School of Medicine at Mount Sinai	2008-09	PHASE4
NCT00043550	COMPLETED	Depression	University of Pennsylvania	2001-11	PHASE3
NCT00093847	COMPLETED	Depression	Massachusetts General Hospital	2004-05	PHASE2
NCT00603018	COMPLETED	Anorexia Nervosa	University of Pittsburgh	2007-06
NCT00361218	COMPLETED	Major Depressive Disorder	Massachusetts General Hospital	2005-10	PHASE3
NCT00168493	UNKNOWN	Major Depression	Baker Heart Research Institute	2000-06
NCT01296802	COMPLETED	Amphetamine-Related Disorders; Amphetamine Abuse	University of Zurich	2006-04
NCT00056472	COMPLETED	Major Depressive Disorder With Psychotic Features	Weill Medical College of Cornell University	2003-01	PHASE3
NCT00343928	COMPLETED	Anorexia Nervosa	Beth Israel Deaconess Medical Center	2006-06	PHASE2
NCT00331799	COMPLETED	Major Depressive Disorder	Duke University	2007-04	PHASE2
NCT00611975	COMPLETED	Healthy	Weill Medical College of Cornell University	2005-10	PHASE4
NCT00296517	COMPLETED	Depressive Disorder	GlaxoSmithKline	2006-01-19	PHASE3
NCT00556140	COMPLETED	Psychotic Depression	Massachusetts General Hospital	2003-06	PHASE3
NCT00564564	COMPLETED	Obsessive Compulsive Disorder	University of Sao Paulo	2006-01	PHASE4
NCT00733668	COMPLETED	Major Depressive Disorder	AstraZeneca	2006-03	PHASE2
NCT00228943	COMPLETED	Breast Cancer	Indiana University	2005-07
NCT00456430	COMPLETED	Depression	Indiana University	2003-07	PHASE4
NCT00249847	TERMINATED	Hot Flashes	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2005-10
NCT01059591	COMPLETED	Depressive Disorder and Anxiety Disorders	GlaxoSmithKline	2006-05-25	PHASE1
NCT01059578	COMPLETED	Depressive Disorder and Anxiety Disorders	GlaxoSmithKline	2006-05-23	PHASE1
NCT01160991	COMPLETED	Schizophrenia; Diabetes; Insulin Resistance	Central Institute of Mental Health, Mannheim	2004-05
NCT00157547	COMPLETED	Major Depressive Disorder	Massachusetts General Hospital	2003-04	PHASE4
NCT00142779	COMPLETED	Cocaine-Related Disorders; Opioid-Related Disorders	National Institute on Drug Abuse (NIDA)	2001-04
NCT00254007	COMPLETED	Depression; Traumatic Brain Injury	Sunnybrook Health Sciences Centre	2003-07	PHASE4
NCT00178971	COMPLETED	Schizophrenia; Schizoaffective Disorder	Northwestern University	2003-01	PHASE3
NCT01282632	COMPLETED	Subjects Had Unipolar, Non-psychotic Major Depression	Sunnybrook Health Sciences Centre	2002-08	PHASE1; PHASE2
NCT00100464	COMPLETED	Obstructive Sleep Apnea	US Department of Veterans Affairs	2000-11	PHASE4
NCT00049972	COMPLETED	Major Depressive Disorder	GlaxoSmithKline	2002-09	PHASE4
NCT00000309	TERMINATED	Cocaine-Related Disorders	Butler Hospital	1994-08	PHASE2
NCT00000310	TERMINATED	Cocaine-Related Disorders	National Institute on Drug Abuse (NIDA)	1996-01	PHASE2
NCT00115362	COMPLETED	Dyspepsia	Radboud University Medical Center	2005-07
NCT00229645	COMPLETED	Major Depression With Comorbid Anxiety Symptoms	Dr Alexander McIntyre Inc.	2003-11	PHASE4
NCT00219505	TERMINATED	Irritable Bowel Syndrome	Penn State University	2001-08
NCT00532519	UNKNOWN	Prurigo Nodularis	Hadassah Medical Organization
NCT00025740	COMPLETED	Post Traumatic Stress Disorder	National Institute of Mental Health (NIMH)	2001-10	PHASE4
NCT00031317	COMPLETED	Panic Disorder	National Institute of Mental Health (NIMH)	2002-02	PHASE4
NCT00263523	COMPLETED	Healthy Volunteers	National Institute of Mental Health (NIMH)	2005-12-05	PHASE1
NCT00227136	TERMINATED	Carcinoid Tumors; Neuroendocrine Tumors	University of Western Ontario, Canada	2005-05	PHASE3
NCT00363506	UNKNOWN	Migraine Disorders	Dynamic Health Resources	2006-01	PHASE4
NCT00226642	UNKNOWN	Depression	Ludwig-Maximilians - University of Munich		PHASE4
NCT00086294	COMPLETED	Parkinson's Disease; Dyskinesias	National Institute of Neurological Disorders and Stroke (NINDS)	2004-06-25	PHASE2
NCT00297505	COMPLETED	Cocaine Dependence	National Institute on Drug Abuse (NIDA)	2001-04	PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-21)

Check the Serotonin Hydrochloride (5-HT HCl) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

As an endogenous agonist, serotonin binds to 5-HT receptor subtypes to activate intracellular G-protein cascades or open ligand-gated ion channels, altering downstream second messenger signaling and cellular excitability. This receptor activation modulates central neurotransmission and peripheral vascular tone, providing the physiological foundation for its clinical relevance in major depressive disorder, sleep disturbances, and vascular conditions evaluated in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).