CAS No. 125941-87-9

Batch: Purity:99.92
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SCH-23390 hydrochloride Chemical Structure
Chemical Structure
Check the SCH-23390 hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride
CAS Number 125941-87-9
Molecular Formula

C17H19Cl2NO
Molecular Weight (MW) 324.24
SMILES CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl.Cl
InChIKey OYCAEWMSOPMASE-XFULWGLBSA-N

Ordering Information

Biological Activity

SCH-23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist targeting D1 and D5 receptors, while also acting as a high-efficacy 5-HT2C receptor agonist and a direct inhibitor of G protein-coupled inwardly rectifying potassium (GIRK) channels. By blocking D1-like receptor signaling and activating 5-HT2C receptors, SCH-23390 hydrochloride modulates dopaminergic and serotonergic neurotransmission pathways, altering intracellular cyclic AMP accumulation and regulating neuronal excitability. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (200.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water 20 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.