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Heptamidine Dimethanesulfonate

Cat.No.S3389

Heptamidine (SBi4211) Dimethanesulfonate is a novel and potent Pentamidine-related inhibitor of the calcium-binding protein S100B with a Kd of 6.9 μM.

Chemical Structure

Molecular Weight: 560.68

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Quality Control

Batch: S338901 DMSO]100 mg/mL]false]Water]5 mg/mL]false]Ethanol]Insoluble]false Purity: 99.77%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.77

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Others Inhibitors	Furimazine (PBI 3939) BAY 2927088（Sevabertinib） Guanidinoacetic acid BAPTA-AM Blebbistatin Silibinin (NSC 651520) Polybrene (Hexadimethrine Bromide) Carbazochrome sodium sulfonate (AC-17) Palmitic acid Osthole

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (178.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 5 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	560.68	Formula	C₂₁H₂₈N₄O₂.2CH₄O₃S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	161374-55-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SBi4211 Dimethanesulfonate			Smiles	C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)C1=CC=C(OCCCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

Mechanism of Action

Targets/IC₅₀/Ki	S100B 6.9 μM(Kd)
References	[1] https://pubmed.ncbi.nlm.nih.gov/23264854/

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