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Robinin TLR Inhibitor

Cat.No.E2758

Robinin is a flavonoid that acts by inhibiting TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin reduces oxidized-LDL-induced TLR2 and TLR4 expression at the mRNA level and prevents NF-κB p65 nuclear translocation by regulating TLR-NF-κB signaling. Robinin exhibits anti-inflammatory and anti-tumor effects.
Robinin TLR Inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 740.66

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Quality Control

Batch: E275801 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.49%
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99.49

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (135.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 740.66 Formula

C33H40O19

 Storage (From the date of receipt)
CAS No. 301-19-9 Download SDF Storage of Stock Solutions

Mechanism of Action

References

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