CAS No. 69308-37-8
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| IUPAC Name | (3R)-4-amino-3-(4-chlorophenyl)butanoic acid | |
|---|---|---|
| CAS Number | 69308-37-8 | |
| Molecular Formula |
C10H12ClNO2 |
|
| Molecular Weight (MW) | 213.66 | |
| SMILES | C1=CC(=CC=C1C(CC(=O)O)CN)Cl | |
| InChIKey | KPYSYYIEGFHWSV-QMMMGPOBSA-N |
(R)-baclofen is a selective agonist of the metabotropic GABAB receptor that functions as the active enantiomer of baclofen. Activation of GABAB receptor complexes inhibits adenylyl cyclase activity and downregulates voltage-gated calcium channels while activating inwardly rectifying potassium channels. These signaling cascades depress presynaptic neurotransmitter release and hyperpolarize postsynaptic neuronal membranes, leading to suppressed excitatory synaptic transmission and attenuated muscle spasticity. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 8 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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