CAS No. 111974-69-7
Batch:
Purity:99.96
Chemical Structure
Check the
Quetiapine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol | |
|---|---|---|
| CAS Number | 111974-69-7 | |
| Molecular Formula |
C21H25N3O2S |
|
| Molecular Weight (MW) | 383.51 | |
| SMILES | C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42 | |
| InChIKey | URKOMYMAXPYINW-UHFFFAOYSA-N |
Quetiapine (ICI 204,636) is an atypical antipsychotic that acts as an antagonist at dopamine D2 receptors and serotonin 5-HT2A receptors, while also displaying binding affinity for 5-HT1A, 5-HT2C, and histamine H1 receptors. By modulating dopaminergic and serotonergic signaling pathways, quetiapine regulates neurotransmission within the central nervous system, suppressing hyperdopaminergic activity and modulating downstream cell signaling to elicit behavioral phenotypes.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.