Molecular Weight: 284.42 g/mol

Promethazine Chemical Structure
Chemical Structure
Check the Promethazine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 29 mg/mL (101.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Chemical Information

IUPAC Name N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
CAS Number 60-87-7
Molecular Formula

C17H20N2S
Molecular Weight (MW) 284.42
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C
InChIKey PWWVAXIEGOYWEE-UHFFFAOYSA-N

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Note: Technical data last updated: Sep 1, 2026.