CAS No. 60-87-7
Batch:
Purity:99.61
Chemical Structure
Check the
Promethazine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine | |
|---|---|---|
| CAS Number | 60-87-7 | |
| Molecular Formula |
C17H20N2S |
|
| Molecular Weight (MW) | 284.42 | |
| SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C | |
| InChIKey | PWWVAXIEGOYWEE-UHFFFAOYSA-N |
Promethazine is a first-generation phenothiazine derivative that acts as a potent histamine H1 receptor antagonist. By competing with endogenous histamine for H1 receptors, it inhibits histamine-mediated signaling pathways, leading to suppressed vascular permeability and reduced smooth muscle contraction. Additionally, promethazine demonstrates antiparasitic properties through the disruption of essential parasite cellular functions and membrane integrity.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(101.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.