PRMT

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7748 EPZ015666(GSK3235025) <1 mg/mL 60 mg/mL 48 mg/mL
S8147 MS049 56 mg/mL 56 mg/mL 50 mg/mL
S8340 SGC2085 <1 mg/mL 62 mg/mL 62 mg/mL
S8479 LLY-283 <1 mg/mL 68 mg/mL 68 mg/mL
S7820 EPZ020411 2HCl 81 mg/mL 100 mg/mL 100 mg/mL
S5445 AMI-1, free acid -1 mg/mL 20 mg/mL -1 mg/mL
S7832 SGC707 <1 mg/mL 59 mg/mL 59 mg/mL
S8112 MS023 <1 mg/mL 57 mg/mL 57 mg/mL
S8664 GSK3326595 (EPZ015938) <1 mg/mL 90 mg/mL 90 mg/mL
S8111 GSK591 <1 mg/mL 76 mg/mL 76 mg/mL
S8209 HLCL-61 HCL <1 mg/mL 76 mg/mL 76 mg/mL
S8624 JNJ-64619178 -1 mg/mL 100 mg/mL -1 mg/mL
S7884 AMI-1 10 mg/mL 100 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7748

EPZ015666(GSK3235025)

EPZ015666(GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.

S8147

MS049

MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively.

S8340

SGC2085

SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.

S8479New

LLY-283

LLY-283 is the potent and selective SAM-competitive chemical probe for PRMT5. It inhibits PRMT5 enzyme activity with IC50 of 20 nM for methylation of an H4R3 derived peptide substrate, and shows greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets.

S7820

EPZ020411 2HCl

EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.

S5445New

AMI-1, free acid

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.

S7832

SGC707

SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.

S8112

MS023

MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.

S8664

GSK3326595 (EPZ015938)

GSK3326595 (EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.

S8111

GSK591

GSK591 (EPZ015866,GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.

S8209

HLCL-61 HCL

HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

S8624

JNJ-64619178

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.

S7884

AMI-1

AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.

Tags: PRMT inhibitor | PRMT activator | PRMT inhibition