CAS No. 887686-02-4
Batch:
Purity:99.01
Chemical Structure
Check the
OSS_128167
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[3-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid | |
|---|---|---|
| CAS Number | 887686-02-4 | |
| Molecular Formula |
C19H14N2O6 |
|
| Molecular Weight (MW) | 366.32 | |
| SMILES | C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O | |
| InChIKey | HTJWLEGCECXGSQ-UHFFFAOYSA-N |
OSS_128167 is a selective sirtuin 6 (SIRT6) inhibitor that displays selectivity over SIRT1 and SIRT2. By inhibiting SIRT6 deacetylase activity, the compound modulates chromatin regulation and gene expression pathways involved in cellular metabolism and viral transcription. Target inhibition leads to suppressed hepatitis B virus (HBV) transcription and replication, attenuating downstream viral proliferation and altering SIRT6-dependent epigenetic regulation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.