CAS No. 23327-57-3
Batch:
Purity:99.98
Chemical Structure
Check the
Nefopam HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;hydrochloride | |
|---|---|---|
| CAS Number | 23327-57-3 | |
| Molecular Formula |
C17H19NO.HCl |
|
| Molecular Weight (MW) | 289.8 | |
| SMILES | CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3.Cl | |
| InChIKey | CNNVSINJDJNHQK-UHFFFAOYSA-N |
Nefopam HCl is a centrally-acting, non-opioid analgesic agent that functions as an inhibitor of voltage-gated sodium channels and monoamine reuptake, including serotonin, dopamine, and noradrenaline transporters. By blocking voltage-gated sodium influx and suppressing neurotransmitter reuptake, it modulates central pain signaling pathways, leading to the attenuation of nociceptive transmission and reduction of neuronal hyperexcitability. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 21 mg/mL |
| DMSO |
1 mg/mL
(3.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 42 mg/mL |
| DMSO |
20 mg/mL
(69.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.