LRRK2
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S7343 | URMC-099 | <1 mg/mL | 84 mg/mL | 6 mg/mL |
| S7368 | GNE-9605 | <1 mg/mL | 89 mg/mL | 12 mg/mL |
| S7367 | GNE-0877 | <1 mg/mL | 67 mg/mL | <1 mg/mL |
| S7584 | LRRK2-IN-1 | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S7528 | GNE-7915 | <1 mg/mL | 22 mg/mL | <1 mg/mL |
| S7664 | GSK2578215A | <1 mg/mL | 79 mg/mL | <1 mg/mL |
LRRK2 Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7343 |
URMC-099URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. |
||
| S7368 |
GNE-9605GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. |
||
| S7367 |
GNE-0877GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM. |
||
| S7584 |
LRRK2-IN-1LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. |
||
| S7528 |
GNE-7915GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and Ki of 9 nM and 1 nM, respectively. |
||
| S7664 |
GSK2578215AGSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7343 |
URMC-099URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. |
||
| S7368 |
GNE-9605GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively. |
||
| S7367 |
GNE-0877GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM. |
||
| S7584 |
LRRK2-IN-1LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. |
||
| S7528 |
GNE-7915GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and Ki of 9 nM and 1 nM, respectively. |
||
| S7664 |
GSK2578215AGSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. |
