LRRK2

All (7) LRRK2 Inhibitors (7) New LRRK2 Products

Catalog No.	Information	Product Use Citations
S6534^New	CZC-54252 CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.
S7343	URMC-099 URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.	FASEB J, 2019, 33(1):1468-1481 Development, 2019, 146(14) Am J Physiol Heart Circ Physiol, 2019, 316(1):H145-H159
S7368	GNE-9605 GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with K_i and IC50 of 2 nM and 19 nM, respectively.
S7367	GNE-0877 GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with K_i of 0.7 nM.
S7584	LRRK2-IN-1 LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
S7528	GNE-7915 GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and K_i of 9 nM and 1 nM, respectively.
S7664	GSK2578215A GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.

Catalog No.	Information	Product Use Citations
S6534^New	CZC-54252 CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.
S7343	URMC-099 URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.	FASEB J, 2019, 33(1):1468-1481 Development, 2019, 146(14) Am J Physiol Heart Circ Physiol, 2019, 316(1):H145-H159
S7368	GNE-9605 GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with K_i and IC50 of 2 nM and 19 nM, respectively.
S7367	GNE-0877 GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with K_i of 0.7 nM.
S7584	LRRK2-IN-1 LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
S7528	GNE-7915 GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor, with IC50 and K_i of 9 nM and 1 nM, respectively.
S7664	GSK2578215A GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.