LC3

Other Autophagy Related Inhibitors

Autophagy LRRK2 OGA Mitophagy ULK Beclin ATTECs Cell wall GluCls

Cat.No.	Product Name	Information	Product Use Citations
S0778	LC3-mHTT-IN-AN1	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. This compound reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
S7683	PIK-III	PIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.	Cell Res, 2025, 10.1038/s41422-025-01085-9 Cell Rep, 2024, 43(1):113575 Sci Rep, 2024, 14(1):4000
E0674	Pennogenin 3-O-β-chacotrioside	Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S0778

LC3-mHTT-IN-AN1

LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. This compound reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.

S7683

PIK-III

PIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.

Cell Res, 2025, 10.1038/s41422-025-01085-9

Cell Rep, 2024, 43(1):113575

Sci Rep, 2024, 14(1):4000

E0674

Pennogenin 3-O-β-chacotrioside

Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.