LC3 antagonist | LC3 inhibitor | LC3 agonist

Catalog No.	Product Name	Information	Product Use Citations
S7683	PIK-III	PIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.	Nat Commun, 2022, 13(1):83 Cell Death Dis, 2022, 13(4):398 Sci Adv, 2021, 7(40):eabj2485
E0674^New	Pennogenin 3-O-β-chacotrioside	Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
S0778	LC3-mHTT-IN-AN1	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
S7683	PIK-III	PIK-III (VPS34-IN2), which is a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.	Nat Commun, 2022, 13(1):83 Cell Death Dis, 2022, 13(4):398 Sci Adv, 2021, 7(40):eabj2485
E0674^New	Pennogenin 3-O-β-chacotrioside	Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
E0674^New	Pennogenin 3-O-β-chacotrioside	Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.

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