CAS No. 36913-39-0
| IUPAC Name | 1-methyl-4-phenylpyridin-1-ium iodide | |
|---|---|---|
| CAS Number | 36913-39-0 | |
| Molecular Formula |
C12H12IN |
|
| Molecular Weight (MW) | 297.13 | |
| SMILES | [I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2 | |
| InChIKey | RFDFRDXIIKROAI-UHFFFAOYSA-M |
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) is a neurotoxic active metabolite of MPTP that models Parkinson's disease phenotypes by selectively targeting dopaminergic neurons in the substantia nigra. It inhibits mitochondrial complex I, triggering energy failure, oxidative stress, and autophagic cell death in SH-SY5Y cells. In addition, MPP+ dysregulates monoamine transport dynamics by modulating dopamine and serotonin transporter localization in neuronal populations. [1][2]
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
72 mg/mL
(242.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 150 mg/mL |
| DMSO |
59 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| DMSO |
59 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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