CAS No. 36913-39-0
Batch:
Purity:99.98
Chemical Structure
Check the
MPP+ iodide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-methyl-4-phenylpyridin-1-ium iodide | |
|---|---|---|
| CAS Number | 36913-39-0 | |
| Molecular Formula |
C12H12IN |
|
| Molecular Weight (MW) | 297.13 | |
| SMILES | [I-].C[N+]1=CC=C(C=C1)C2=CC=CC=C2 | |
| InChIKey | RFDFRDXIIKROAI-UHFFFAOYSA-M |
Biological Activity
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide) is a neurotoxic active metabolite of MPTP that models Parkinson's disease phenotypes by selectively targeting dopaminergic neurons in the substantia nigra. It inhibits mitochondrial complex I, triggering energy failure, oxidative stress, and autophagic cell death in SH-SY5Y cells. In addition, MPP+ dysregulates monoamine transport dynamics by modulating dopamine and serotonin transporter localization in neuronal populations. [1][2]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
72 mg/mL
(242.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 72 mg/mL |
| Water | 150 mg/mL |
| DMSO |
59 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| DMSO |
59 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.