CAS No. 130-37-0

Batch: Purity:99.92
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Menadione bisulfite sodium Chemical Structure
Chemical Structure
Check the Menadione bisulfite sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 2-methyl-1,4-dioxo-3H-naphthalene-2-sulfonate
CAS Number 130-37-0
Molecular Formula

C11H9NaO5S
Molecular Weight (MW) 276.24
SMILES [Na+].CC1(CC(=O)C2=CC=CC=C2C1=O)[S]([O-])(=O)=O
InChIKey XDPFHGWVCTXHDX-UHFFFAOYSA-M

Ordering Information

Biological Activity

Menadione bisulfite sodium is a fat-soluble synthetic analog of vitamin K that acts as an inhibitor of protein phosphatase Cdc25 and mitochondrial DNA polymerase γ. Inhibition of Cdc25 blocks cell cycle progression by preventing cyclin-dependent kinase activation, whereas inhibition of mitochondrial DNA polymerase γ suppresses mitochondrial DNA replication, promotes oxidative stress through reactive oxygen species accumulation, and induces cellular apoptosis. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 55 mg/mL (199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 55 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.