CAS No. 2495096-26-7
Batch:
Purity:99.99
Chemical Structure
Check the
Lartesertib (M4076)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoro-5-methoxy-4-pyridinyl)-7-methoxy-3-methylimidazo[4,5-c]quinolin-2-one | |
|---|---|---|
| CAS Number | 2495096-26-7 | |
| Molecular Formula |
C23H21FN6O3 |
|
| Molecular Weight (MW) | 448.45 | |
| InChIKey | WNEFOSMCGCLLJU-UHFFFAOYSA-N |
Lartesertib (M4076) is a selective inhibitor of ataxia telangiectasia-mutated (ATM) kinase with sub-nanomolar potency. By blocking ATM catalytic activity, it suppresses DNA double-strand break (DSB) repair and abrogates cell-cycle checkpoint activation within the DNA damage response pathway. Consequently, this disruption impairs clonogenic cancer cell growth, increases structural chromosomal defects, and potentiates the antitumor activity of ionizing radiation and ATR inhibitors. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(200.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.