CAS No. 479-50-5
Batch:
Purity:99.87
Chemical Structure
Check the
Lucanthone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one | |
|---|---|---|
| CAS Number | 479-50-5 | |
| Molecular Formula |
C20H24N2OS |
|
| Molecular Weight (MW) | 340.48 | |
| SMILES | CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O | |
| InChIKey | FBQPGGIHOFZRGH-UHFFFAOYSA-N |
Lucanthone is an orally available thioxanthone-based DNA intercalator that acts as an inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APE1) and autophagy. By inhibiting APE1 activity within the base excision repair pathway and disrupting lysosomal function to impair autophagic flux, it causes accumulation of unaddressed DNA lesions and blocks autophagic degradation, ultimately suppressing cell proliferation and inducing apoptosis.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 68 mg/mL |
| DMSO |
33 mg/mL
(96.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.