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Imeglimin (EMD 387008) Hydrochloride ROS Production Reducer

Name: Imeglimin (EMD 387008) Hydrochloride
Brand: Selleck Chemicals
SKU: S9925
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S9925

Imeglimin (EMD 387008, IMEG, PXL 008, RVT-1501) Hydrochloride is a new class of oral glucose-lowering agents. Imeglimin normalizes glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative stress and favoring lipid oxidation in liver of HFHSD mice.

Chemical Structure

Molecular Weight: 191.66

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Quality Control

Batch: Purity: 99.99%

99.99

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other ROS Inhibitors	MitoQ (Mitoquinone) Mesylate Piperlongumine H2DCFDA (DCFH-DA) Gallic acid Neohesperidin Pyrogallol Idebenone Disufenton sodium Carnosic acid (20R)Ginsenoside Rg3

Solubility

In vitro
Batch:

DMSO : 38 mg/mL (198.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 38 mg/mL

Ethanol : 38 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.900mg/ml (9.91mM)	Taking the 1 mL working solution as an example, add 50 μL of 38 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.900mg/ml (9.91mM)	Taking the 1 mL working solution as an example, add 50 μL of 38 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	191.66	Formula	C₆H₁₃N₅.ClH	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	775351-61-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	PXL 008 Hydrochloride, RVT-1501 Hydrochloride, IMEG Hydrochloride			SMILES	Cl.CC1N=C(N)NC(=N1)N(C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro	Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death.<sup><a class="sref" href="#s_ref">[2]</a></sup>
In vivo	Imeglimin normalizes glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative stress and favoring lipid oxidation in liver of high-fat, high-sucrose diet (HFHSD) mice.<sup><a class="sref" href="#s_ref">[1]</a></sup>
References	[1] https://pubmed.ncbi.nlm.nih.gov/25552598/ [2] https://pubmed.ncbi.nlm.nih.gov/27551496/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-09)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05366868	ACTIVE_NOT_RECRUITING	Diabetes Mellitus, Type 2	National Center for Global Health and Medicine, Japan	2022-05-26	PHASE4
NCT07436182	NOT_YET_RECRUITING	Mitochondria; Metformin	Mansoura University	2026-03-01	PHASE4
NCT07691177	COMPLETED	Type 2 Diabetes	Humanis Saglık Anonim Sirketi	2026-02-06	PHASE1
NCT07127094	COMPLETED	Bioequivalence Study in Healthy Subjects	Aya Mohammed Abdel Magid Abdel Hamid	2025-03-09	PHASE1
NCT03802786	COMPLETED	Hepatic Impairment	Poxel SA	2018-11-06	PHASE1
NCT03802786	Completed	Hepatic Impairment	Poxel SA	2018-11-06	Phase 1

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Handling Instructions

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