CAS No. 141626-36-0
Batch:
Purity:99.53
Chemical Structure
Check the
Dronedarone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide | |
|---|---|---|
| CAS Number | 141626-36-0 | |
| Molecular Formula |
C31H44N2O5S |
|
| Molecular Weight (MW) | 556.76 | |
| SMILES | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC | |
| InChIKey | ZQTNQVWKHCQYLQ-UHFFFAOYSA-N |
Dronedarone is a non-iodinated amiodarone derivative that functions as a multichannel Class III antiarrhythmic agent. It exhibits rate-dependent inhibition of rapid sodium currents, non-selective block of outward potassium currents, suppression of slow inward calcium currents, and inhibition of alpha- and beta-adrenergic receptors. Through these combined ion channel and receptor blockade mechanisms, dronedarone prolongs cardiac action potential duration and effective refractory period, suppressing re-entrant cardiac arrhythmias. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(179.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.