CAS No. 3737-09-5
Batch:
Purity:99.02
Chemical Structure
Check the
Disopyramide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide | |
|---|---|---|
| CAS Number | 3737-09-5 | |
| Molecular Formula |
C21H29N3O |
|
| Molecular Weight (MW) | 339.47 | |
| SMILES | CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C | |
| InChIKey | UVTNFZQICZKOEM-UHFFFAOYSA-N |
Disopyramide is a class IA antiarrhythmic agent that acts as a cardiac sodium channel blocker. By inhibiting phase 0 of the cardiac action potential, it suppresses membrane depolarization, depresses conduction velocity, and prolongs refractory periods in myocardial tissue. Furthermore, disopyramide exhibits negative inotropic effects and anticholinergic activity through interaction with cardiac muscarinic acetylcholine receptors, thereby modulating cellular excitability and AV nodal conduction. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.