CAS No. 25459-91-0
Batch:
Purity:99.01
Chemical Structure
Check the
Demethyleneberberine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol | |
|---|---|---|
| CAS Number | 25459-91-0 | |
| Molecular Formula |
C19H18NO4 |
|
| Molecular Weight (MW) | 324.35 | |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O | |
| InChIKey | HVTCKKMWZDDWOY-UHFFFAOYSA-O |
Demethyleneberberine is a natural alkaloid derivative that acts as an AMPK pathway activator and NF-κB signaling pathway inhibitor. By activating AMPK and suppressing NF-κB signaling, it significantly reduces the expression of pro-inflammatory cytokines, including IL-6 and TNF-α, and diminishes myeloperoxidase activity. Downstream, these effects attenuate weight loss, inhibit inflammatory responses, and protect against non-alcoholic fatty liver disease.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(9.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Demethyleneberberine Clinical Trials
- Demethyleneberberine Solubility in DMSO
- Demethyleneberberine Stock Solution
- Demethyleneberberine Storage
- Demethyleneberberine Stability
- Demethyleneberberine Molecular Weight
- Demethyleneberberine SMILES
- Demethyleneberberine Chemical Structure (2D and 3D)
- Demethyleneberberine SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.