CORM-3

Catalog No.S7448 Batch:S744801

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Technical Data

Formula

C5 H4 Cl N O5 Ru
Molecular Weight 294.61 CAS No. 475473-26-8
Solubility (25°C)* In vitro DMSO 38 mg/mL (128.98 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
In vitro CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. [1] CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. [2] CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. [4]
In vivo CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. [1] CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. [3]

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    CBA mice transplanted with BALB/c hearts.

  • Dosages

    ~40 mg/kg daily

  • Administration

    i.p.

Selleck's CORM-3 has been cited by 7 publications

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer [ Cell Death Discov, 2024, 10(1):42] PubMed: 38263152
CORM-3 exerts a neuroprotective effect in a rodent model of traumatic brain injury via the bidirectional gut-brain interactions [ Exp Neurol, 2021, 341:113683] PubMed: 33711325
Carbon Monoxide-Releasing Molecule-3 Alleviates Kupffer Cell Pyroptosis Induced by Hemorrhagic Shock and Resuscitation via sGC-cGMP Signal Pathway [ Inflammation, 2021, 10.1007/s10753-021-01419-w] PubMed: 33575924
Carbon Monoxide-Releasing Molecule-3 Ameliorates Acute Lung Injury in a Model of Hemorrhagic Shock and Resuscitation: Roles of p38MAPK Signaling Pathway [ Shock, 2021, 55(6):816-826] PubMed: 33105439
Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation [Zheng G EBioMedicine, 2019, 10.1016/j.ebiom.2018.12.059] PubMed: 30612943
Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation. [ Free Radic Biol Med, 2019, 141:299-309] PubMed: 31265876
A fluorescent probe for carbon monoxide based on allyl ether rather than allyl ester: A practical strategy to avoid the interference of esterase in cell imaging. [ Talanta, 2019, 205:120070] PubMed: 31450480

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.