CD38 inhibitor 1 (compound 78c): Selectivity & Specificity
CD38 inhibitor 1 (compound 78c) is a potent inhibitor of human CD38 enzyme (7.3 nM), mouse CD38 enzyme (1.9 nM), recombinant human CD38 (17.7 nM), murine CD38 (liver) (3.8 nM), murine CD38 (skeletal muscle) (4.4 nM), murine CD38 (spleen) (0.7 nM), murine CD38 (brain) (14.8 nM), murine CD38 (ileum) (0.4 nM), murine CD38 (subcutaneous fat) (5.2 nM). CD38 inhibitor 1 (compound 78c) exhibits the greatest inhibitory potency toward murine CD38 (ileum) (IC50 = 0.4 nM).