Home Cytoskeletal Signaling Microtubule Associated inhibitor Auristatin E

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Auristatin E Microtubule Associated inhibitor

Cat.No.S0561

Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.
Auristatin E Microtubule Associated inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 732.01

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Chemical Information, Storage & Stability

Molecular Weight 732.01 Formula

C40H69N5O7

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CAS No. 160800-57-7 Download SDF Storage of Stock Solutions

Mechanism of Action

In vivo

Auristatin E (0.25 mg/kg, s.c., a single dose for 80 days) inhibits tumor growth in nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts.
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