Home Cytoskeletal Signaling Microtubule Associated inhibitor - Other inhibitor Auristatin E

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Auristatin E Microtubule Associated inhibitor

Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.

Auristatin E Microtubule Associated inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 732.01

Purity & Quality Control

Related Products

Signaling Pathway

Microtubule Associated Signaling Pathways

Microtubule Associated Signaling Pathway

Mechanism of Action

In Vivo
In vivo

Auristatin E (0.25 mg/kg, s.c., a single dose for 80 days) inhibits tumor growth in nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts.

References
  • https://pubmed.ncbi.nlm.nih.gov/12778055/
  • https://www.freepatentsonline.com/6884869.html
  • https://europepmc.org/article/PAT/EP1482972

Chemical Information

Molecular Weight 732.01 Formula

C40H69N5O7
CAS No. 160800-57-7 SDF Download SDF
Smiles CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O

Storage and Stability

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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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