CAS No. 29608-49-9

Batch: Purity:99.23
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Almitrine mesylate Chemical Structure
Chemical Structure
Check the Almitrine mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine;methanesulfonic acid
CAS Number 29608-49-9
Molecular Formula

C28H37F2N7O6S2
Molecular Weight (MW) 669.76
SMILES C[S](O)(=O)=O.C[S](O)(=O)=O.FC1=CC=C(C=C1)C(N2CCN(CC2)C3=NC(=NC(=N3)NCC=C)NCC=C)C4=CC=C(F)C=C4
InChIKey MRDBGMJEPGXQHJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Almitrine mesylate is a pharmacologically unique respiratory stimulant that acts as an agonist of peripheral chemoreceptors located on carotid bodies. By inhibiting calcium-dependent potassium channel activity and reducing channel open probability, the compound depolarizes carotid body glomus cells. This physiological action stimulates downstream sensory afferent signaling pathways, promoting hyperventilation and significantly enhancing systemic arterial oxygenation. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (149.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.