Risedronate Sodium

Catalog No.S1428 Synonyms: NE 58095 Sodium

Risedronate Sodium Chemical Structure

Molecular Weight(MW): 305.09

Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.

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Biological Activity

Description Risedronate Sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.
In vitro

Risedronate causes a total inhibition of colony formation whereas Etidronate has relatively little effect in calcifying fibroblastic colony-forming unit (CFU-f) cultures of rat bone marrow cells in vitro. Risedronate (1 μM) decreases the formation of colonies displaying osteoblastic characteristics such as alkaline phosphatase expression, collagen accumulation, and calcification. Risedronate (1 nM) and alendronate increases the formation of fibroblastic colonies, suggesting a mild anabolic effect, however, the formation of colonies with osteoblastic properties is not affected. [1] Risedronate significantly inhibits expression of c-Fos and nuclear factor of activated T cells (NFAT) c1 induced by RANKL in bone marrow-derived macrophages (BMMs). [2]

In vivo Risedronate (1 mg/kg) significantly increases the volumetric densities of bone (Vb) and osteoblast Vob and decreases Vm more prominently in rats. [3] Risedronate causes a significant and dose-dependent reduction of tooth movement after the orthodontic force is applied in rats. [4] Risedronate prevents a reduction in periosteal bone formation and an increase in endocortical bone erosion, resulting in prevention of alterations in percent cortical bone and marrow areas. Risedronate increases osteocyte density and lacunar occupancy and prevented a GC-induced increase in cortical porosity. Risedronate and Vitamin K(2) has additive effects on osteocyte density and lacunar occupancy and a synergistic effect on cortical porosity. [5]

Protocol

Solubility (25°C)

In vitro Water 2 mg/mL (6.55 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 305.09
Formula

C7H10NNaO7P2

CAS No. 115436-72-1
Storage powder
in solvent
Synonyms NE 58095 Sodium

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03411902 Recruiting Bariatric Surgery Candidate|Bone Loss|Weight Loss Wake Forest University Health Sciences|Wake Forest University June 15 2018 Phase 4
NCT03411902 Recruiting Bariatric Surgery Candidate|Bone Loss|Weight Loss Wake Forest University Health Sciences|Wake Forest University June 15 2018 Phase 4
NCT03208582 Completed Osteogenesis Imperfecta Sheffield Children''s NHS Foundation Trust April 1 2017 Phase 2
NCT03208582 Completed Osteogenesis Imperfecta Sheffield Children''s NHS Foundation Trust April 1 2017 Phase 2
NCT00460733 Completed Colles'' Fracture Sanofi|Procter and Gamble March 2007 Phase 4
NCT00460733 Completed Colles'' Fracture Sanofi|Procter and Gamble March 2007 Phase 4

Tech Support

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID