CAS No. 34183-22-7
Batch:
Purity:99.78
Chemical Structure
Check the
Propafenone HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride | |
|---|---|---|
| CAS Number | 34183-22-7 | |
| Molecular Formula |
C21H27NO3.HCl |
|
| Molecular Weight (MW) | 377.9 | |
| SMILES | CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl | |
| InChIKey | XWIHRGFIPXWGEF-UHFFFAOYSA-N |
Propafenone HCl is a class IC anti-arrhythmic agent that acts as a cardiac sodium channel blocker. By inhibiting the influx of sodium ions into cardiac muscle cells, it reduces cell excitability and slows cardiac impulse conduction. Downstream, this suppression of sodium currents attenuates rapid cardiac action potentials, mitigating atrial and ventricular arrhythmias and enabling its use in modeling heart failure in animals. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3.125 mg/mL
(8.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.