CAS No. 13241-33-3

Batch: Purity:99.63
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Neohesperidin Chemical Structure
Chemical Structure
Check the Neohesperidin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 13241-33-3
Molecular Formula

C28H34O15
Molecular Weight (MW) 610.56
SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O

Ordering Information

Biological Activity

Neohesperidin is a naturally occurring flavanone glycoside isolated from citrus fruits that acts as an antioxidant and free radical-scavenging agent. It inhibits P-glycoprotein-mediated transport to decrease the efflux of cellular substrates, while demonstrating antiproliferative activity against Caco-2 and leukemia cell lines. In addition, neohesperidin attenuates gastric mucosal lesions and modulates gastric secretion, protecting tissues against oxidative stress and inflammatory injury. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (163.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.