Magnolol

For research use only.

Catalog No.S2321 Synonyms: NSC 293099

5 publications

Magnolol Chemical Structure

CAS No. 528-43-8

Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.

Selleck's Magnolol has been cited by 5 publications

1 Customer Review

  • Magnolol reduces RNV areas and avascular areas in OIR mice. Mice retinas from OIR group (a, b) and OIR + Magnolol (25 mg/kg) group (c, d) were harvested at P17 and subjected to wholemount immunostaining with IB4 (red), showing neovascular areas (green) and avascular areas (yellow).

    Inflamm Res, 2016, 65(1):81-93. Magnolol purchased from Selleck.

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Biological Activity

Description Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.
Targets
NF-κB [4]
()
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. [1] Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. [2]

In vivo

LD50: Mice 2200mg/kg (i.g.). [3]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (199.0 mM)
Ethanol 53 mg/mL (199.0 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.33
Formula

C18H18O2

CAS No. 528-43-8
Storage powder
in solvent
Synonyms NSC 293099
Smiles C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

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