CAS No. 204205-90-3
Batch:
Purity:99.82
Chemical Structure
Check the
Indibulin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide | |
|---|---|---|
| CAS Number | 204205-90-3 | |
| Molecular Formula |
C22H16ClN3O2 |
|
| Molecular Weight (MW) | 389.83 | |
| SMILES | C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C(=O)NC4=CC=NC=C4 | |
| InChIKey | SOLIIYNRSAWTSQ-UHFFFAOYSA-N |
Biological Activity
Indibulin (ZIO-301, D-24851) is an orally active inhibitor of tubulin assembly with potent antitumor activity. By destabilizing the microtubule network, it disrupts mitotic spindle formation during cell division. This inhibition leads to cell cycle arrest at the G2/M phase and induces apoptotic cell death across various cancer cell lines, demonstrating antiproliferative efficacy with low neurotoxicity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(102.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.