Docetaxel is a potent microtubule stabilizer. It affects PI3K/Akt/mTOR and apoptosis-related signaling pathways. By binding to microtubules with high affinity and disrupting microtubule dynamics, it induces G2/M cell cycle arrest, thereby inhibiting tumor cell proliferation, migration, and promoting apoptosis.
Docetaxel IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Docetaxel Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.