CAS No. 1428-95-1
Batch:
Purity:98.96
Chemical Structure
Check the
5-(N,N-Hexamethylene)-amiloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1428-95-1 | |
|---|---|---|
| Molecular Formula |
C12H18ClN7O |
|
| Molecular Weight (MW) | 311.77 |
5-(N,N-Hexamethylene)-amiloride is an amiloride derivative that acts as a potent inhibitor of the Na⁺/H⁺ exchanger and the HIV-1 Vpu ion channel. Inhibition of Na⁺/H⁺ exchange lowers intracellular pH and induces apoptosis in target cells. Furthermore, it suppresses the replication of mouse hepatitis virus (MHV) with an EC₅₀ ofand human coronavirus 229E (HCoV-229E) with an EC₅₀ ofin cultured L929 cells. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(198.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 5-(N,N-Hexamethylene)-amiloride Solubility in DMSO
- 5-(N,N-Hexamethylene)-amiloride Stock Solution
- 5-(N,N-Hexamethylene)-amiloride Storage
- 5-(N,N-Hexamethylene)-amiloride Stability
- 5-(N,N-Hexamethylene)-amiloride Molecular Weight
- 5-(N,N-Hexamethylene)-amiloride Chemical Structure (2D and 3D)
- 5-(N,N-Hexamethylene)-amiloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.