Home Immunology & Inflammation TLR agonist 1V209 (TLR7 agonist T7)

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1V209 (TLR7 agonist T7) TLR agonist

Cat.No.S0078

1V209 (TLR7 agonist T7) is an agonist of Toll-like receptor 7 (TLR7) with anti-tumor effects. It can be used as vaccine adjuvants and enhances antigen specific humoral and cellular immune responses.
1V209 (TLR7 agonist T7) TLR agonist Chemical Structure

Chemical Structure

Molecular Weight: 359.34

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S007801 DMSO]72 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 359.34 Formula
C16H17N5O5
 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1062444-54-5 -- Storage of Stock Solutions

Synonyms T7 Smiles COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=C(C=C3)C(=O)O)N

Solubility

In vitro
Batch:

DMSO : 72 mg/mL (200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
TLR7 [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06007794 Not yet recruiting
Cancer|Post-cancer|Hematology
Hospices Civils de Lyon
 April 1 2024 Not Applicable
NCT06112483 Not yet recruiting
Specific Learning Disorder|Intellectual Disability Mild to Moderate|Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder|Physical Disability
Chinese University of Hong Kong
 November 15 2023 --
NCT06203665 Completed
Atelectasis|Compliance Patient
Panagiota Griva|National and Kapodistrian University of Athens
 June 7 2023 Not Applicable
NCT05594550 Not yet recruiting
Acute Respiratory Distress Syndrom (SARS-Cov 2)
Centre Hospitalier Universitaire Dijon
 October 2022 --

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