CAS No. 1062444-54-5

Batch: Purity:99.86
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1V209 (TLR7 agonist T7) Chemical Structure
Chemical Structure
Check the 1V209 (TLR7 agonist T7) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]benzoic acid
CAS Number 1062444-54-5
Molecular Formula
C16H17N5O5
Molecular Weight (MW) 359.34
SMILES COCCOC1=NC(=C2C(=N1)N(C(=O)N2)CC3=CC=C(C=C3)C(=O)O)N
InChIKey ATISKRYGYNSRNP-UHFFFAOYSA-N

Biological Activity

1V209 is a potent Toll-like receptor 7 (TLR7) agonist that exhibits marked immunostimulatory and anti-tumor activity. Activation of TLR7 triggers downstream NF-kB signaling and type I interferon production, leading to the activation of antigen-presenting cells. As a vaccine adjuvant, 1V209 enhances antigen-specific humoral and cellular immune responses, boosting cytokine secretion and anti-tumor immunity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Wu CC, et al. J Innate Immun. 2014;6(3):315-24.

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Note: Technical data last updated: Sep 1, 2026.