1-Phenylbiguanide

For research use only.

Catalog No.S2578 Synonyms: Phenylbiguanide, PBG, N-Phenylbiguanide

1-Phenylbiguanide Chemical Structure

Molecular Weight(MW): 177.21

1-phenylbiguanide (PBG) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.

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Biological Activity

Description 1-phenylbiguanide (PBG) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.

Protocol

Solubility (25°C)

In vitro DMSO 35 mg/mL (197.5 mM)
Water 35 mg/mL (197.5 mM)
Ethanol 17 mg/mL (95.93 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 177.21
Formula

C8H11N5

CAS No. 102-02-3
Storage powder
in solvent
Synonyms Phenylbiguanide, PBG, N-Phenylbiguanide

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

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Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04373967 Not yet recruiting Drug: Victoza®.|Drug: Metformin Hydrochloride|Drug: TQZ2451 Type 2 Diabetes Chia Tai Tianqing Pharmaceutical Group Co. Ltd. May 1 2020 Phase 3
NCT03547297 Terminated -- Acute Hepatic Porphyria|Hepatic Porphyrias|Acute Intermittent Porphyria (AIP)|Hereditary Coproporphyria (HCP)|Variegate Porphyria (VP)|ALA Dehydratase Deficient Porphyria (ADP)|Porphyria Acute Alnylam Pharmaceuticals May 29 2018 --
NCT03505853 Completed Drug: Givosiran|Drug: 5-probe cocktail Acute Intermittent Porphyria (AIP)|Acute Hepatic Porphyria (AHP)|Porphyria Acute Intermittent|Acute Porphyria Alnylam Pharmaceuticals April 26 2018 Phase 1
NCT03338816 Active not recruiting Drug: Givosiran|Drug: Placebo Acute Hepatic Porphyria|Acute Intermittent Porphyria|Porphyria Acute Intermittent|Acute Porphyria|Hereditary Coproporphyria (HCP)|Variegate Porphyria (VP)|ALA Dehydratase Deficient Porphyria (ADP) Alnylam Pharmaceuticals November 16 2017 Phase 3
NCT02949830 Active not recruiting Drug: givosiran (ALN-AS1) Acute Intermittent Porphyria Alnylam Pharmaceuticals October 2016 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID