Catalog No.S2578 Synonyms: Phenylbiguanide, PBG, N-Phenylbiguanide

For research use only.

1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.

1-Phenylbiguanide Chemical Structure

CAS No. 102-02-3

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Biological Activity

Description 1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.
5-HT3 receptor [1]
(Cell-free assay)
3.0 μM(EC50)

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 35 mg/mL
(197.5 mM)
Water 35 mg/mL
(197.5 mM)
Ethanol '17 mg/mL

Chemical Information

Molecular Weight 177.21


CAS No. 102-02-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)N=C(N)N=C(N)N

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04373967 Recruiting Drug: Victoza®.|Drug: Metformin Hydrochloride|Drug: TQZ2451 Type 2 Diabetes Chia Tai Tianqing Pharmaceutical Group Co. Ltd. April 29 2020 Phase 3
NCT04618354 Completed Other: No interventions Diabetes Shanghai 10th People''s Hospital January 1 2019 --
NCT03547297 Terminated -- Acute Hepatic Porphyria|Hepatic Porphyrias|Acute Intermittent Porphyria (AIP)|Hereditary Coproporphyria (HCP)|Variegate Porphyria (VP)|ALA Dehydratase Deficient Porphyria (ADP)|Porphyria Acute Alnylam Pharmaceuticals May 29 2018 --
NCT03505853 Completed Drug: Givosiran|Drug: 5-probe cocktail Acute Intermittent Porphyria (AIP)|Acute Hepatic Porphyria (AHP)|Porphyria Acute Intermittent|Acute Porphyria Alnylam Pharmaceuticals April 26 2018 Phase 1
NCT03338816 Completed Drug: Givosiran|Drug: Placebo Acute Hepatic Porphyria|Acute Intermittent Porphyria|Porphyria Acute Intermittent|Acute Porphyria|Hereditary Coproporphyria (HCP)|Variegate Porphyria (VP)|ALA Dehydratase Deficient Porphyria (ADP) Alnylam Pharmaceuticals November 16 2017 Phase 3
NCT02949830 Completed Drug: givosiran (ALN-AS1) Acute Intermittent Porphyria Alnylam Pharmaceuticals October 2016 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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