CAS No. 102-02-3
Batch:
Purity:99.50
Chemical Structure
Check the
1-Phenylbiguanide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 102-02-3 | |
|---|---|---|
| Molecular Formula |
C8H11N5 |
|
| Molecular Weight (MW) | 177.21 | |
| SMILES | C1=CC=C(C=C1)N=C(N)N=C(N)N |
1-Phenylbiguanide is a selective 5-hydroxytryptamine3 (5-HT3) receptor agonist. By binding to ligand-gated 5-HT3 ion channel receptors, it induces rapid membrane depolarization and extracellular cation influx in central and peripheral neurons. This selective channel activation subsequently modulates neurotransmitter release and regulates downstream neuronal signaling pathways involved in visceral sensory perception and reflex responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
35 mg/mL
(197.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 35 mg/mL |
| Ethanol | 17 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.