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MAT2A

Other Methylation Related Inhibitors

EZH2 PRMT LSD1 JMJD G9a/GLP SETD MLL COMT DOT1 HNMT
Cat.No. Product Name Information Product Use Citations Product Validations
S9872 AG-270 AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels and MTAP-null–selective antiproliferative activity.
S0435 PF-9366  PF-9366 is a human methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.
Nat Commun, 2024, 15(1):8971
Nature Communications, 2024, 8971
J Oral Microbiol, 2024, 16(1):2292375
E1485 IDE397 (GSK-4362676) IDE397 (GSK-4362676) is a potent inhibitor of MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.
E1806 AGI-24512 AGI-24512 is an inhibitor of MAT2A with an IC50 of 8 nM. It increases R-Loop formation and DNA damage in MTAP-deleted and WT cell models. It also exhibits anti-proliferative activity in vitro.