COMT inhibitor | COMT activator | COMT chemical

Catalog No.	Product Name	Information	Product Use Citations
S4021	Tolcapone	Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.	FASEB J, 2022, 36(7):e22399 Viruses, 2021, 13(8)1533 Front Bioinform, 2021, 1:710591
S3147	Entacapone	Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.	Elife, 2022, 11e72668 bioRxiv, 2021, 10.1101/2021.03.22.436393
S6938	Opicapone	Opicapone(BIA 9-1067) is a potent inhibitor of catechol-O-methyltransferase (COMT) with ED50 values of 1.4 mg⋅kg⁻¹ in rat erythrocytes. It has the potential to be used in research of Parkinson's disease and motor fluctuations.
S4021	Tolcapone	Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.	FASEB J, 2022, 36(7):e22399 Viruses, 2021, 13(8)1533 Front Bioinform, 2021, 1:710591
S3147	Entacapone	Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.	Elife, 2022, 11e72668 bioRxiv, 2021, 10.1101/2021.03.22.436393
S6938	Opicapone	Opicapone(BIA 9-1067) is a potent inhibitor of catechol-O-methyltransferase (COMT) with ED50 values of 1.4 mg⋅kg⁻¹ in rat erythrocytes. It has the potential to be used in research of Parkinson's disease and motor fluctuations.

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