LSD1

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7237 OG-L002 <1 mg/mL 45 mg/mL 19 mg/mL
S7574 GSK-LSD1 2HCl 57 mg/mL 57 mg/mL -1 mg/mL
S7795 ORY-1001 (RG-6016) 2HCl 61 mg/mL 5 mg/mL 4 mg/mL
S7680 SP2509 <1 mg/mL 38 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7237

OG-L002

OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.

S7574

GSK-LSD1 2HCl

GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).

S7795

ORY-1001 (RG-6016) 2HCl

ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.

S7680

SP2509

SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.

Tags: LSD1 inhibitor | LSD1 modulator | LSD1 chemical