SETD

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7570 UNC0379 <1 mg/mL 82 mg/mL <1 mg/mL
S7294 PFI-2 HCl 4 mg/mL 99 mg/mL 25 mg/mL
S7983 A-196 <1 mg/mL 15 mg/mL 12 mg/mL
S4635 Cyproheptadine hydrochloride sesquihydrate <1 mg/mL 70 mg/mL 13 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7570

UNC0379

UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.9 μM, high selectivity over 15 other methyltransferases.

S7294

PFI-2 HCl

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

S7983

A-196

A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.

S4635

Cyproheptadine hydrochloride sesquihydrate

Cyproheptadine hydrochloride is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.

Tags: SETD inhibitor | SETD activator | SETD inhibition