TC-E 5003

For research use only.

Catalog No.S0855 Synonyms: NSC 30176

TC-E 5003 Chemical Structure

CAS No. 17328-16-4

TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.

Purity & Quality Control

Choose Selective PRMT Inhibitors

Biological Activity

Description TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.
Targets
PRMT1 [1]
(Cell-free assay)
1.5 μM

Protocol

Solubility (25°C)

In vitro DMSO 80 mg/mL (199.37 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 401.26
Formula

C16H14Cl2N2O4S

CAS No. 17328-16-4
Storage powder
in solvent
Synonyms NSC 30176

In vivo Formulation Calculator (Clear solution)

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Dilution Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID