PRMT1 Selective Inhibitors

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S0855	TC-E 5003	TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.	Selective	PRMT1, IC50: 1.5 μM
S7884	AMI-1	AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.	Selective	human PRMT1, IC50: 8.8 μM
S6737	C7280948	C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro.	Selective	PRMT1, IC50: 12.8 μM
S5445	AMI-1 (free acid)	AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.	Selective
S8858	GSK3368715 3HCl	GSK3368715 3HCl is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Ki^app vaules ranging from 1.5 to 81 nM.	Pan
S8112	MS023	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.	Pan	PRMT1, IC50: 30 nM
S7820	EPZ020411 2HCl	EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.	Pan	PRMT1, IC50: 119 nM